在患有生长激素缺乏症的儿童中,区域同质性的变化取决于频率
Ju-Rong Ding1, Yihong Liu1, Qiang Chen1
1School of Automation and Information Engineering, Sichuan University of Science and Engineering, Zigong, PR China; Artificial Intelligence Key Laboratory of Sichuan Province, Sichuan University of Science and Engineering, Zigong, PR China.
患有生长激素缺乏症 (GHD) 的儿童在特定频段中表现出异常的大脑活动. 休息状态的fMRI显示了与健康对照组相比,GHD患者的明显区域同质性 (ReHo) 差异.
科学领域:
- 神经科学是一个神经科学.
- 儿科内分泌学 儿科内分泌学
- 放射学 放射学是一门学科.
背景情况:
- 以前的休息状态功能磁共振成像 (rs-fMRI) 研究表明,生长激素缺乏症 (GHD) 儿童的神经活动异常自发.
- 在GHD的不同频段内,自发神经活动的特定变化仍然在很大程度上未被描述.
研究的目的:
- 通过rs-fMRI和区域同质性 (ReHo) 分析,在不同的频段中调查GHD儿童的自发神经活动.
- 为了确定GHD儿童和年龄和性别匹配的健康对照 (HC) 之间的大脑活动的频段特定差异.
主要方法:
- 从26名GHD儿童和15名HC获得了rs-fMRI数据.
- 区域同质性 (ReHo) 计算并比较了四个频段:慢-5 (0.014-0.031 Hz),慢-4 (0.031-0.081 Hz),慢-3 (0.081-0.224 Hz) 和慢-2 (0.224-0.25 Hz).
- 进行了统计分析,以确定每个频段内GHD儿童和HC之间ReHo的显著差异.
主要成果:
- 与HC相比,在GHD儿童的不同频段的多个大脑区域中观察到显著的ReHo差异.
- 具体发现包括前额,顶额,部,部和带区域的ReHo变化,根据频段而有所不同 (例如,缓慢-5中左上额前环中ReHo增加,缓慢-4中左上额顶环中ReHo减少,缓慢-2中右前带带环中ReHo增加).
- 这些异常是广泛的,并且取决于频段.
结论:
- 在GHD儿童中,区域大脑活动表现出广泛的,频段特定的异常.
- 这些发现为GHD的神经基础提供了新的见解,并可能有助于我们理解其病理生理学.
- 鉴定出的变化凸显了在神经和内分泌疾病中考虑频率特异的神经动态的重要性.
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