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相关概念视频

Allergic Drug Reactions01:27

Allergic Drug Reactions

898
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
898
Hypersensitivities01:30

Hypersensitivities

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
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Allergic Reactions02:06

Allergic Reactions

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Overview
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Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

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Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
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Pharmacovigilance01:19

Pharmacovigilance

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Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
903
Drug Excretion: Miscellaneous Routes01:10

Drug Excretion: Miscellaneous Routes

88
Drug excretion involves various organs, including the liver, intestines, skin, and eyes. In the case of drugs or toxins, they can be actively secreted into bile by transporters in the hepatocyte's canalicular membrane. These substances enter the GI tract during digestion and may be reabsorbed into the body from the intestine. This process, known as enterohepatic recycling, can significantly prolong the presence and effects of a substance in the body. To interrupt this cycle, specific...
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相关实验视频

Updated: Jul 24, 2025

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
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Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

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药物过敏反应 药物过敏反应

R Gentry Wilkerson1

  • 1Department of Emergency Medicine, University of Maryland School of Medicine, 110 South Paca Street, 6th Floor, Suite 200, Baltimore, MD 21201, USA.

Immunology and allergy clinics of North America
|July 2, 2023
PubMed
概括
此摘要是机器生成的。

药物过敏反应 (DHRs) 涉及对药物的免疫反应. 了解盖尔和库姆斯分类,包括过敏反应和严重皮肤不良反应 (SCAR),对于急诊医生至关重要.

关键词:
药物不良反应 药物不良反应过敏反应 (ANAPHYLAXIS) 是一种过敏反应.药物过敏 药物过敏 药物过敏药物过敏症 药物过敏症过敏反应过敏反应严重的皮肤不良反应

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相关实验视频

Last Updated: Jul 24, 2025

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
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科学领域:

  • 免疫学 免疫学 免疫学
  • 皮肤病学 皮肤病学
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 药物过敏反应 (DHRs) 是对药物的免疫中介反应.
  • 根据盖尔和库姆斯的分类,免疫性DHR根据机制被分为四种主要类型.
  • 对于像过敏反应这样的立即反应,及时识别和治疗至关重要.

研究的目的:

  • 概述免疫药物过敏反应的各种病理生理学类别.
  • 区分即时的过敏反应和发展缓慢的过敏反应.
  • 强调紧急医生理解DHRs对于患者评估和管理的重要性.

主要方法:

  • 对免疫学DHRs的盖尔和库姆斯分类系统的审查.
  • 基于免疫机制的DHRs的分类.
  • 讨论特定反应类型,包括过敏反应和严重皮肤不良反应 (SCAR).

主要成果:

  • 过敏反应被确定为I型过敏反应,需要立即医疗照顾.
  • 严重的皮肤不良反应 (SCARs) 包括DRESS,SJS,TEN和AGEP,这些都是由IV型过敏引起的.
  • 一些DHRs发展缓慢,不需要紧急干预.

结论:

  • 紧急医生需要对各种DHR有全面的了解.
  • 了解DHR分类有助于适当的患者评估和治疗策略.
  • 区分立即和延迟反应对于有效的紧急护理至关重要.