[了解功能神经系统疾病:从生物标志物到病理生理模型]
Ismael Conejero1, Eric Thouvenot2, Coraline Hingray3
1Département de psychiatrie, CHU de Nîmes, PSNREC, Inserm, université de Montpellier, Nîmes, France.
L'Encephale
|July 2, 2023
概括
功能神经系统障碍涉及由生物脆弱性和压力影响的复杂大脑网络功能障碍. 了解这些生物心理社会因素是有效的患者护理和治疗开发的关键.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医学生物学 医学生物学
背景情况:
- 功能神经障碍 (FNDs) 已经被广泛使用神经成像研究了二十多年.
- 研究综合是必要的,以了解当前的发现和病因学假设.
- 本综述旨在帮助临床医生和患者了解FNDs的生物学基础.
研究的目的:
- 综合最近关于神经成像和功能神经障碍的生物学研究成果.
- 审查这些疾病所提出的病因学假设.
- 增强对FND机制的临床理解和患者知识.
主要方法:
- 进行了对国际出版物的叙事审查.
- 该审查涵盖了神经成像和功能神经障碍生物学研究.
- 文献搜索范围从1997年到2023年.
主要成果:
- 几个大脑网络都涉及到FND,影响认知资源,注意力,情绪调节,代理和整体感知.
- 应激反应机制与FND症状有关.
- 生物心理社会模型,整合脆弱性 (生物学,表观遗传) 和压力 (压力诊断模型),解释了FND表型,导致情绪障碍并影响控制过程.
结论:
- 了解FND中大脑网络功能障碍的生物心理社会决定因素至关重要.
- 这种知识对于开发有针对性的治疗方法至关重要.
- 更好的理解对于患者护理和功能神经症状的管理至关重要.
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