肠道病毒脑膜炎没有囊细胞症:成年人的回顾性观察性研究
Dongkeun Roh1, Woochan Jeon2, Jisook Lee1
1Department of Emergency Medicine, Ajou University School of Medicine, Republic of Korea.
Japanese journal of infectious diseases
|July 2, 2023
概括
没有细胞瘤的肠道病毒 (EV) 脑膜炎在成年人中很常见,而不仅仅是儿童. 诊断需要RT-PCR,特别是高脑液蛋白和压力,即使白细胞数量正常.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 之前,只有在儿科患者中记录了无细胞病的肠道病毒 (EV) 脑膜炎.
- 这种疾病涉及由肠道病毒引起的脑膜炎症,通常以脑脊液 (CSF) 中白细胞数量的增加为特征.
研究的目的:
- 为了研究成年患者在没有细胞瘤的情况下发生EV脑膜炎的频率.
- 为了比较成年人EV脑膜炎的临床特征,有和没有细胞瘤.
主要方法:
- 通过大脑脊髓液 (CSF) 反转录聚合酶链反应 (RT-PCR) 诊断出EV脑膜炎的成年患者的回顾性分析.
- 临床数据的比较,包括CSF分析 (白细胞计数,蛋白质水平,血压) 在患有细胞病和没有细胞病的患者之间.
主要成果:
- 在研究中的成人脑膜炎病例中,58.8%没有表现出斑细胞.
- 在细胞体和非细胞体组之间没有观察到年龄,临床症状或季节性的显著差异.
- 没有细胞症的患者的外周白细胞数量较低,但显示出CSF压力较高和CSF蛋白质水平正常或升高的趋势.
结论:
- 没有细胞瘤的肠道病毒脑膜炎在成年人中经常发生.
- RT-PCR确认对于诊断患有脑膜炎症状的成年人中脑膜炎的诊断至关重要,脑液中蛋白质升高,脑液中白细胞数量正常,特别是在EV爆发期间.
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