患有视神经低增生和视性视觉失生症的儿童的危险因素
Michael S Salman1, Chelsea A Ruth2, Marina S Yogendran3
1Section of Pediatric Neurology, Department of Pediatrics and Child Health, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
Developmental medicine and child neurology
|July 3, 2023
概括
孕妇在怀孕期间吸烟是光神经缺血症 (ONH) 和阴道光学形症 (SOD) 的关键可改变的危险因素. 年轻的母亲年龄和初怀孕也是这些疾病的相关风险因素.
科学领域:
- 眼科医生 眼科 眼科
- 遗传学 是一个遗传学.
- 产科 产科 产科 产科 产科
背景情况:
- 视神经过度增生 (ONH) 和视失生 (SOD) 是一种先天性疾病,影响视力和发育.
- 以前的研究已经确定了各种产前风险因素,但往往缺乏对混偏差的强有力的控制.
研究的目的:
- 识别和确认ONH和SOD的产前风险因素.
- 区分可修改和不可修改的风险因素.
- 为了解决以前报告的关联中的潜在混偏见.
主要方法:
- 根据1990-2019年加拿大卫生数据进行了一项回顾性,基于人口的病例控制研究.
- ONH/SOD病例与无关的基于人口的对照和兄弟对照相匹配.
- 多变量条件逻辑回归分析了母亲风险因素与ONH/SOD发展之间的关联.
主要成果:
- 怀孕时较年轻的母亲年龄 (OR=0.91),初怀孕 (OR=3.39),以及母亲吸烟 (OR=2.86) 在无关的对照队列中与ONH/SOD显著相关.
- 在兄弟对照队列中,母亲吸烟仍然是显著的风险因素 (OR=3.65).
结论:
- 产前风险因素,无论是可修改的还是不可修改的,都与ONH和SOD有关.
- 怀孕期间母亲吸烟被确定为主要可修改的风险因素.
- 基于人口的数据与匹配的对照对准确识别风险因素至关重要,最大限度地减少混偏差.
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