孕妇血清内分泌水平是妊娠糖尿病的新标志物吗?
Elif Yıldız1, Fatma Ketenci Gencer1, Burcu Timur2
1Department of Obstetrics and Gynecology, Gaziosmanpaşa Training and Research Hospital, İstanbul, Turkey.
The journal of obstetrics and gynaecology research
|July 3, 2023
概括
在怀孕期糖尿病 (GDM) 的孕妇中,血清内分泌水平显著更高. 这些升高的水平与血糖控制标志物相关,这表明内分泌干细胞.
科学领域:
- 内分泌学 在内分泌学.
- 生物化学 生物化学
- 生殖医学 生殖医学
背景情况:
- 孕期糖尿病 (GDM) 是一种常见的妊娠并发症.
- 生物标志物对于早期GDM检测和监测至关重要.
研究的目的:
- 为了研究有或没有GDM的孕妇的血清内分泌水平.
- 评估血清内分泌和GDM指标之间的相关性.
主要方法:
- 对90名孕妇进行前性病例对照研究 (45名孕妇,45名对照).
- 血清内分泌细胞水平通过ELISA测量.
- 使用两步协议进行GDM选.
主要成果:
- 血清内分泌水平在GDM组显著更高 (p < 0.001).
- 内分泌水平与50g口服葡萄糖挑战测试 (GCT) 结果,禁食葡萄糖,食后葡萄糖和HbA1c (p < 0.001) 有正相关.
- ROC分析表明,内分泌对GDM检测具有55.6%的灵敏度和88.9%的特异性 (AUC:0.737).
结论:
- 血清内分泌的升高与GDM有关,与血糖控制相关.
- 恩多坎显示出作为GDM新型生物标志物的潜力,需要在更大的队列中进行进一步的研究.
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