功能和结构网络在普遍的强力克隆性中脱,并通过药物进行重组
Haonan Pei1,2, Shuai Ma1,2,3, Wei Yan1,2
1The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Epilepsia open
|July 3, 2023
概括
综合性强力-克隆性发作 (GTCS) 涉及到大脑网络障碍. 抗发作药物 (ASM) 可以使功能连接正常化,表明它们作为疗效指标的潜力.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 的研究研究.
背景情况:
- 综合性强力-克隆性 (GTCS) 与大规模的大脑网络障碍有关.
- 了解这些网络变化以及抗发作药物 (ASM) 的影响对于治疗优化至关重要.
研究的目的:
- 调查未经治疗的GTCS患者的功能和结构网络障碍.
- 评估ASM对这些大脑网络的影响.
主要方法:
- 利用静止状态功能磁共振成像 (rs-fMRI) 和扩散张力成像 (DTI) 在41名GTCS患者 (21未治疗,20接受治疗) 和29名健康对照中.
- 分析了结构和功能连接,包括网络级加权关联概率 (NWCP).
主要成果:
- 未经治疗的GTCS患者表现出增强的功能和结构连接,特别是涉及默认模式网络 (DMN) 和正面-双侧网络.
- 接受治疗的患者表现出正常化的功能连接,而结构性改变在所有患者群体中都存在.
- 在网络内和网络之间,ASM逆转了未经治疗的患者中观察到的NWCP下降.
结论:
- GTCS涉及到重要的结构和功能连接性改变.
- ASM似乎能使功能网络干扰正常化,对功能和结构合都有潜在的好处.
- 结构功能连接合状态可以作为ASM有效性的生物标志物.
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