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针对瘤-瘤微环境的交叉通话

Sunil S Badve¹, Yesim Gökmen-Polar¹

¹Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.

Expert opinion on therapeutic targets

|July 3, 2023

概括

向癌细胞及其微环境 (TME) 是克服治疗耐药性的有希望的策略. 共同向瘤-TME相互作用可以改善癌症控制和临床结果.

科学领域:

在瘤学瘤学.
癌症生物学癌症生物学
免疫学免疫学免疫学

背景情况:

癌症的发展涉及癌细胞及其微环境 (TME) 的复杂的共同进化.
传统疗法主要针对癌细胞,经常忽视关键的T-TME相互作用.
瘤-TME交叉对话和异质性对治疗耐药性有着显著的贡献.

研究的目的:

审查瘤TME系统的组件.
探索共同向瘤和TME元素的潜力,以改善癌症治疗方法.
讨论在抗癌治疗中针对TME组件的策略.

主要方法:

在PubMed和ClinicalTrials.gov的文献综述,截至2023年5月.
对T-TME相互作用及其在癌症进展中的作用的分析.
在临床前和临床环境中评估共同准方法.

主要成果:

在一些模型中,共同准瘤和TME组件在预防瘤进展和转移方面取得了成功.
了解组织特异性T-TME相互作用对于治疗反应至关重要.
存在各种策略,以准TME组件在抗癌疗法.

结论:

对瘤和TME的双重向有望提高癌症控制.
考虑组织背景和瘤类型对于优化治疗策略至关重要.
对T-TME相互作用的进一步研究可以改善临床结果.

关键词:

瘤是一个瘤.瘤微环境是一个微环境.癌症进展癌症进展双重目标是双重的目标.互动是一种互动.转移转移转移转移

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