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长非编码RNA在子宫内膜异位症进展中的作用
Yong Liu1, Wensi Zhang2, Lingge Jin1
1Department of Gynecology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, 100026 Beijing, China.
Frontiers in bioscience (Landmark edition)
|July 3, 2023
概括
长非编码RNAs (lncRNAs) 显示为诊断子宫内膜异位症 (EMs) 的生物标志物具有前途. 本综述探讨了EMS中的lncRNA功能和机制,突出了它们在早期检测和改善患者治疗结果方面的潜力.
科学领域:
- 妇科 妇科医生 妇科
- 分子生物学分子生物学
- 生物标志物发现发现
背景情况:
- 子宫内膜异位症 (EMs) 是一种流行的妇科疾病,发病率正在上升.
- 由于缺乏特定生物标志物的延迟诊断,严重影响患者的生活质量.
- 有效的分子生物标志物对于早期EMS诊断和治疗至关重要.
研究的目的:
- 审查与EMs相关的长非编码RNAs (lncRNAs) 的生物特征和功能.
- 阐明EM中lncRNAs的机制,包括ceRNA网络,外体,缺氧和反意义RNA.
- 讨论 lncRNAs 作为子宫内膜异位症生物标志物的潜在临床应用.
主要方法:
- 对与EMs相关的lncRNAs的高通量测序研究的文献综述.
- 关于子宫内膜异位症中的lncRNA功能和机制的实验证据的摘要.
- 在EMs病变发生过程中分析特定的lncRNAs,如H19和MALAT1.
主要成果:
- lncRNAs通过各种分子机制在子宫内膜异位病原体中发挥着不同的作用.
- 像H19和MALAT1这样的特定的lncRNA与EMS的发展和进展有关.
- lncRNAs因其作为EMS诊断和治疗点的潜力而越来越被认可.
结论:
- lncRNAs代表了对子宫内膜异位症的一个有前途的分子生物标志物.
- 对lncRNA机制的进一步研究可以为EM患者提供早期诊断和个性化治疗策略.
- 克服临床应用中的挑战将释放lncRNAs在治疗子宫内膜异位症方面的全部潜力.
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