连续活性消毒抹布对重症监护室环境生物负担的有效性:一项随机对照研究
Gita Nadimpalli1, J Kristie Johnson2, Laurence S Magder1
1Department of Epidemiology and Public Health, The University of Maryland School of Medicine, Baltimore, Maryland.
Infection control and hospital epidemiology
|July 3, 2023
概括
与标准消毒剂相比,一种新的持续活性消毒剂 (CAD) 并没有显著降低细菌生物负担或在表面检测流行病学重要病原体 (EIP). 需要进一步的研究来确认在临床环境中CAD的疗效.
科学领域:
- 感染控制和医院流行病学
- 环境卫生环境卫生
- 微生物学 微生物学
背景情况:
- 在重症监护室 (ICU) 的高接触环境表面是病原体的储存库.
- 有效的消毒对于预防医疗相关感染至关重要.
- 持续活性消毒剂 (CAD) 在环境卫生方面提供了潜在的进步.
研究的目的:
- 为了比较新的CAD擦拭剂与标准消毒剂在减少ICU表面生物负担方面的有效性.
- 评估CAD对流行病学重要病原体 (EIP) 检测的影响.
主要方法:
- 在医疗重症监护室 (MICU) 进行了一项单盲随机对照试验.
- 包括接触预防措施的成年患者.
- 使用CAD或标准消毒剂清洗前,清洗后1,4小时和24小时收集了环境表面样本.
主要成果:
- 在清洗后24小时,CAD的平均生物负担为52 CFU/mL,标准消毒剂为92 CFU/mL.
- 在CAD和标准消毒剂之间的平均生物负担的差异不是统计学上显著的 (-0.59;95% CI,-1.45到0.27).
- 检测流行病学重要病原体的几率在CAD下降了14% (OR,0.86;95%CI,0.31-2.32),但这在统计学上并不显著.
结论:
- 该研究发现,在24小时后,CAD和标准消毒剂之间的细菌生物负担或EIP检测没有统计学上显著的差异.
- 虽然CAD在体外显示出有前途的结果,但其临床疗效需要进一步研究.
- 建议进行更大的研究,以验证CAD技术在现实世界医疗保健环境中的有效性.
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