在前吸烟者中,在三年后减少了通气道总计数和通气道壁缩
Paulina V Wyszkiewicz1,2, Maksym Sharma1,2, Vedanth Desaigoudar1,2
1Robarts Research Institute, Western University, London, Ontario, Canada.
纵向CT扫描显示,COPD前吸烟者呼吸道重塑,呼吸道总数减少,呼吸道壁在三年内变薄. 空气道壁厚度预测CT扫描的恶化,这表明其在控制COPD进展方面的有用性.
科学领域:
- 肺部医学 肺部医学
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 慢性阻塞性肺病 (COPD) 的严重程度会影响气道测量,但纵向变化尚未得到充分了解.
- 前吸烟者是研究COPD进展和呼吸道改造的关键人群.
- 之前的研究表明,CT呼吸道指标在COPD各个阶段的横截面差异.
研究的目的:
- 为了评估计算机断层扫描 (CT) 呼吸道测量的纵向变化,在3年内,在有或没有COPD的前吸烟者中进行测量.
- 评估气道改造,肺的进展和肺功能之间的关系.
- 为了确定基线气道壁厚度是否可以预测总气道数量的未来变化.
主要方法:
- 对患有 (n=50) 和没有 (n=40) COPD 的前吸烟者的前性研究,评估在基线和3年随访.
- 使用CT扫描进行呼吸道总计数 (TAC),呼吸道壁面积 (WA),面积 (LA) 和壁面积百分比 (WA%).
- 量化肺瘤 (RA950) 和使用3HeMRI进行通风缺陷百分比 (VDP);使用配对t测试和多变量模型分析了变化.
主要成果:
- 在这两组中,FEV1没有显著变化,但肺气 (RA950) 在两组中都恶化.
- 患有COPD的前吸烟者在三年内显著减少了TAC,WA,LA和WA%.
- 基线气道壁厚度预测TAC恶化,TAC仅在COPD患者下降,在所有前吸烟者中观察到更薄的气道壁.
结论:
- 在患有COPD的前吸烟者中,CT衍生的气道改造参数在三年内发生显著变化.
- 空气道壁厚度是COPD疾病进展的潜在预测因素.
- 纵向CT气道分析可以作为管理COPD和预测其进展的宝贵工具.
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