重度痴呆症抑郁症的工具:一个范围审查
Christina Wang1, Eliot Roberts2, Greg Smith2
1The University of New South Wales, Faculty of Medicine, Sydney, New South Wales, Australia.
International journal of geriatric psychiatry
|July 3, 2023
概括
识别帮助停止严重痴呆症不适当药物的工具至关重要. 目前的抑郁症描述工具显示临床益处有限,强调需要对患者结果进行更多研究.
科学领域:
- 老年医学 老年医学
- 药理学 药理学是指药理学的学科.
- 基于证据的实践.
背景情况:
- 在严重痴呆症中识别不合适的药物是具有挑战性的,但对于减少不良事件和改善生活质量至关重要.
- 降低处方的目的是优化药物治疗方案,以获得更好的患者结果.
研究的目的:
- 确定已出版的工具,旨在协助重度痴呆症患者的抑郁症描述.
- 在临床实践中评估这些抑郁症工具在临床实践中所报告的有用性.
主要方法:
- 在多个数据库 (Medline,EMBASE,Cochrane图书馆等) 中进行了全面的范围审查. 从开始到2023年4月.
- 工具被广泛定义,包括指导方针,算法和药物特定建议.
- 来自12项纳入研究的数据使用叙事合成进行了合成.
主要成果:
- 十二项研究产生了12种描述工具,分为干预措施,共识标准和药物特定建议.
- 在严重痴呆症患者群体中测试了10种工具,但只有一个研究报告了药物戒断的明显临床益处.
- 有限证据表明,抑郁症对患者的结果,如认知变化和不良事件的影响是有限的.
结论:
- 目前用于重度痴呆症的抑郁症工具的临床实用性受到严重缺乏关于药物戒断效应的强有力的证据的限制.
- 进一步的研究重点关注患者的结果,包括认知功能和不良事件,对于验证这些工具至关重要.
- 增强的证据生成将澄清减记工具在管理严重痴呆症患者复杂药物治疗方案中的作用.
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