细菌社区改变了宿主基因对幼儿脏的影响
F Blostein1, T Zou2, D Bhaumik1
1Department of Epidemiology, University of Michigan School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Journal of dental research
|July 3, 2023
概括
口腔微生物组显著影响儿童早期 (ECC) 风险,与遗传易感性相互作用. 识别和预防空性口腔微生物组为减少ECC发病率提供了普遍的好处.
科学领域:
- 口腔健康 口腔健康
- 微生物学 微生物学
- 遗传学 遗传学 是一个
背景情况:
- 幼儿 (ECC) 影响大约20%的5岁儿童.
- 口腔微生物组和宿主遗传学都与ECC易感性有关.
- 口腔微生物组与对ECC的遗传倾向之间的相互作用在很大程度上仍未被探索.
研究的目的:
- 调查唾液细菌组是否会改变长度出生队列中遗传易感性 (多基因得分) 和ECC之间的关联.
- 确定遗传风险和唾液细菌群体状态类型 (CST) 对ECC发育的独立和相互作用影响.
主要方法:
- 使用全基因组关联数据构建了初级牙的多基因分数 (PGS).
- 普森回归被用来评估PGS和ECC发病率之间的关联.
- 唾液细菌组数据 (24个月) 和ECC状态 (60个月) 分析了细菌社区状态类型 (CST) 的效果修改.
主要成果:
- 高的PGS与增加的ECC发病率没有显著关联.
- 在24个月的卡里奥基因唾液细菌CST与60个月的ECC有很强的关联 (OR,7.48).
- 在唾液细菌CST和PGS之间观察到显著的相互作用 (P=0.04),其中PGS仅在患有非焦性CST的儿童中与ECC相关.
结论:
- 口腔微生物组在修改对ECC的遗传敏感性方面发挥着关键作用.
- 对ECC的遗传风险可能会被口腔微生物组合掩盖或放大.
- 向和防止 cariogenic 口腔微生物群的殖民可能是一个普遍有益的策略,用于ECC预防跨不同的遗传风险概况.
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