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在黑色素瘤中增强免疫疗法反应:作为治疗点的髓状腺衍生抑制细胞

Feyza Gul Ozbay Kurt^1,2,3,4, Samantha Lasser^1,2,3,4, Ihor Arkhypov^1,2,3,4

¹Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.

The Journal of clinical investigation

|July 3, 2023

概括

骨髓系衍生抑制细胞 (MDSCs) 驱动对黑色素瘤免疫疗法的抗性. 针对这些细胞提供了一个有希望的策略,以提高免疫检查点抑制剂 (ICI) 在癌症治疗中的有效性.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
癌症研究癌症研究

背景情况:

免疫检查点抑制剂 (ICI) 已在黑色素瘤治疗中取得成功.
对ICI的耐药性仍然是黑色素瘤的重大临床问题.
骨髓原抑制细胞 (MDSCs) 是免疫抑制和瘤生长的关键参与者.

研究的目的:

审查黑色素瘤中MDSC介导的免疫抑制机制.
总结研究MDSC向的临床前和临床研究.
探索抑制MDSC功能以改善ICI治疗的策略.

主要方法:

对MDSCs和黑色素瘤免疫治疗研究的文献综述.
对MDSC介导的免疫抑制背后的机制的分析.
评估当前和新兴的MDSC准策略.

主要成果:

MDSCs创造了一个免疫抑制瘤微环境,有助于ICI耐药性.
向MDSC可能会克服耐药性并增强抗瘤免疫力.
目前正在探索各种策略来抑制MDSC功能.

结论:

MDSCs是克服黑色素瘤ICI耐药性的关键目标.
抑制MDSC活性是改善黑色素瘤免疫治疗结果的一个有希望的方法.
对MDSC向策略的进一步研究是有必要的,以提高癌症治疗效率.

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Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.