认知分类中的稳定性作为损伤严重程度和种族的函数:纵向分析
Fernanda Arruda1, Mónica Rosselli1,2, Andrea Mejia Kurasz3
1Department of Psychology, Charles E. Schmidt College of Science, Florida Atlantic University, Davie, FL.
Applied neuropsychology. Adult
|July 3, 2023
概括
种族没有影响阿尔茨海默病的生物标志物或认知衰退的进展. 然而,海马和脑内皮层缩预测了轻度认知障碍的进展,西班牙裔/拉丁裔和欧洲裔美国人群体之间的逆转率有显著差异.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 阿尔茨海默氏症疾病研究研究
背景情况:
- 人种,认知衰退和阿尔茨海默病 (AD) 神经成像生物标志物之间的相互作用尚未得到充分理解.
- 研究认知状态分类和进展中的种族差异对于理解AD至关重要.
- 之前的研究还没有完全阐明神经成像标记在认知障碍进展的背景下如何在各族群之间存在差异.
研究的目的:
- 检查跨种族群体认知状态分类 (认知正常[CN]和轻度认知障碍[MCI]) 的稳定性.
- 为了比较具有稳定或变化的认知诊断的西班牙裔/拉丁裔和欧洲裔美国人之间的神经成像生物标志物 (结构性MRI,粉样蛋白PET).
- 在不同的人群中识别认知进展和逆转的预测因素.
主要方法:
- 209名参与者 (124名西班牙裔/拉丁裔,85名欧洲裔美国人) 经过一段时间的认知状态评估.
- 结构性MRI和粉样蛋白PET扫描被用于评估神经成像生物标志物.
- 认知状态被分类为认知正常 (CN) 或轻度认知障碍 (MCI),分析进展和逆转.
主要成果:
- 跨诊断类别的西班牙裔/拉丁裔和欧洲裔美国人群体之间没有发现神经成像生物标志物的显著差异.
- 认知进步者和非进步者的频率在各族群之间没有显著差异.
- 在基线时,海马体 (HP) 和脑内皮层 (ERC) 缩预测了这两个组的进展. 在进步的西班牙裔/拉丁裔个体中,ERC缩更为明显. 在欧洲裔美国人中,MCI进展者数量超过逆转者 (60%),而在西班牙裔/拉丁裔中,MCI逆转者数量超过进展者 (7%). 在MCI参与者中,MMSE和HP/ERC缩预测了进展.
结论:
- 种族似乎没有影响神经成像生物标志物差异或阿尔茨海默病的整体认知进展率.
- 基线海马体和脑内皮层缩是MCI患者认知能力下降的关键预测因素.
- 从MCI到CN的逆转率存在显著的种族差异,这表明潜在的潜在生物学或环境因素影响了疾病的发展轨迹.
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