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Updated: Jul 24, 2025

Measuring Microbial Mutation Rates with the Fluctuation Assay
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Measuring Microbial Mutation Rates with the Fluctuation Assay

Published on: November 28, 2019

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人类基因组突变速率变化的结构性基础

Zian Liu1, Md Abul Hassan Samee1

  • 1Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.

Nucleic acids research
|July 3, 2023
PubMed
概括

DNA 形状会影响人类基因组中的单核酸突变率. 结构性DNA特征,如螺旋式扭转和倾斜,解释了突变变异性,改善了遗传疾病和人类进化模型.

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Studying Ribonucleotide Incorporation: Strand-specific Detection of Ribonucleotides in the Yeast Genome and Measuring Ribonucleotide-induced Mutagenesis

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Spontaneous mutations arise infrequently during DNA replication due to errors in the process. A key factor behind these errors is tautomeric shifts in nitrogenous bases, where bases transition from keto to enol forms or amino to imino forms. This shift can alter base-pairing rules, leading to mutations. Additionally, reactive oxygen species (ROS) arising from aerobic metabolism can damage DNA, resulting in depurination (loss of a purine base) or depyrimidination (loss of a pyrimidine base).
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