转移性割抵抗性前列腺癌的免疫疗法组合 - 失败的试验和未来的方面
1Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Current opinion in urology
|July 3, 2023
概括
使用检查点抑制剂的前列腺癌免疫疗法未能改善生存率. 针对独特癌症抗原的新策略,包括疫苗和CAR T细胞,对未来的治疗有希望.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症治疗方法 癌症治疗方法
背景情况:
- 前列腺癌免疫疗法,特别是免疫检查点阻塞,在临床试验中没有显示出显著的生存益处.
- 尽管进行了广泛的研究,但涉及检查点抑制剂的组合疗法未能满足总生存 (OS) 和无放射性进展生存 (rPFS) 的初级终点.
研究的目的:
- 审查目前前列腺癌免疫治疗的现状.
- 突出目前基于检查点抑制剂的治疗方法的局限性.
- 探索针对独特癌症抗原的新兴免疫治疗策略.
主要方法:
- 审查最近的第三期临床试验,涉及前列腺癌检查点抑制剂.
- 分析针对特定细胞表面抗原的新型免疫学策略.
- 评估新兴的治疗平台,如疫苗,CAR T 细胞,双特异性 T 细胞参与剂和抗体药物合物.
主要成果:
- 检查点抑制剂,单独或与化疗,PARP抑制剂或其他生物药物结合使用,对整体存活率或无放射性进展存活率没有显著的益处.
- 新的免疫学策略专注于各种独特的泛癌抗原,这些抗原在多种癌症类型中表达.
- 这些新的策略包括治疗性疫苗,仿真抗原受体 (CAR) T 细胞疗法,双特异性T 细胞参与剂和抗体-药物合物.
结论:
- 虽然检查点抑制剂的成功有限,但对向免疫疗法的持续研究对于推进前列腺癌治疗至关重要.
- 开发针对独特瘤抗原的疗法是改善前列腺癌患者治疗结果的有希望的途径.
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