间歇性肺病中的肺高血压和慢性阻塞性肺病中的肺高血压:不同的实体?
Lucilla Piccari1, Ricardo Aguilar-Colindres2, Diego A Rodríguez-Chiaradía1,3,4
1Department of Pulmonary Medicine, Hospital del Mar.
Current opinion in pulmonary medicine
|July 3, 2023
概括
慢性阻塞性肺病 (COPD) 和间歇性肺病 (ILD) 中的肺高血压 (PH) 有一些相似之处,但具有不同的特征. 认识到这些差异对于在这些慢性肺部疾病中管理PH至关重要.
科学领域:
- 肺血管疾病是肺血管疾病.
- 心脏肺部医学 心脏肺部医学
背景情况:
- 肺高血压 (PH) 是慢性阻塞性肺病 (COPD) 和间歇性肺病 (ILD) 的常见并发症,被归类为第三组PH.
- 对于COPD和ILD之间PH的表现和行为的确切相似之处和区别仍然不完全理解.
研究的目的:
- 本综述旨在界定COPD与ILD的背景下PH的发病,临床表现,自然史和治疗反应的共同点和差异.
- 它还试图确定第三组PH的未来研究的关键领域.
主要方法:
- 对与慢性肺部疾病相关的PH最近文献进行了全面的审查.
- 分析病因因素,临床特征,疾病进展和治疗结果.
- 在COPD和ILD中比较PH,考虑到潜在的肺病理和血液动力学严重程度.
主要成果:
- 慢性肺病中PH的病原性因素正在重新评估,传统因素如缺氧和烟草暴露与空气中的污染物和遗传突变等新兴因素相结合.
- 检查了与COPD和ILD相关的PH的常见和分歧的临床特征,自然史模式和治疗反应.
- 肺血管疾病的不同模式,受到特定肺部状况和血液动力学参与的影响,越来越多地被认可.
结论:
- 在COPD和ILD患者中,PH显著增加了发病率和死亡率.
- 需要进一步的研究来阐明PH在这些条件下的独特模式,特别是在疾病的早期阶段.
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