系统性审查:自闭症谱系障碍和肠道微生物群
Jenni Korteniemi1, Linnea Karlsson1,2,3, Anna Aatsinki1,2
1FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, Psychiatry, University of Turku, Turku, Finland.
Acta psychiatrica Scandinavica
|July 3, 2023
概括
与神经类型儿童相比,患有自闭症谱系障碍 (ASD) 的儿童表现出改变的肠道微生物群. 特定的细菌,如蛋白质细菌和活性细菌,在更高的水平上被发现,这表明潜在的治疗点.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 儿科 儿科 儿科
背景情况:
- 自闭症谱系障碍 (ASD) 的病因尚不清楚,尽管对其神经精神方面的研究.
- 肠-大脑轴及其与ASD症状的联系越来越多地被研究.
- 虽然肠道微生物群和自闭症之间的相关性已被注意到,但个体微生物的功能在很大程度上是未知的.
研究的目的:
- 审查当前关于ASD和儿童肠道微生物群之间的关系的科学证据.
- 阐明自闭症谱系障碍和肠道微生物组成之间的相互关系.
主要方法:
- 系统的文献审查.
- 专注于2-18岁的儿童.
- 分析了关于肠道微生物群组成,干预措施和潜在机制的研究结果.
主要成果:
- 在患有自闭症儿童的肠道微生物群落中观察到显著的差异.
- 在自闭症儿童中,总是发现高水平的蛋白质细菌,活性细菌和沙特雷拉菌.
- 在不同研究中,多样性指数和分类学丰度的变化被注意到.
结论:
- 患有自闭症儿童的肠道微生物组成不同于神经类型发育的儿童.
- 需要进一步的研究来探索ASD的潜在生物标志物和针对肠道微生物群的治疗干预措施.
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