一种稳定的幻影材料用于光学和声学成像
Lina Hacker1, Aoife M Ivory2, James Joseph3
1Department of Physics, University of Cambridge; Cancer Research UK Cambridge Institute, University of Cambridge.
Journal of visualized experiments : JoVE
|July 3, 2023
概括
一种新的,稳定的,负担得起的组织模拟材料被开发用于校准生物医学成像设备. 这种生物光子幻影材料支持光声学,光学和超声技术的标准化.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 光学和声学 视觉和声学
背景情况:
- 标准化生物医学成像设备对于在机构和供应商之间比较结果至关重要.
- 开发稳定,模仿组织的幻影材料对于新型成像技术的临床转化至关重要.
研究的目的:
- 提出一种稳定,低成本,模仿组织材料的制造工艺,用于光声学,光学和超声波标准化.
- 为了使多功能幻影应用程序的声学和光学特性能够独立调整.
主要方法:
- 一种油中的共聚合物材料是使用矿物油和一个共聚合物合成的.
- 声学特性 (声音的速度,衰减) 和光学特性 (吸收,散射) 的特征.
- 使用光声成像证实了材料的同质性.
主要成果:
- 该材料在5MHz时的声音速度为1,481 ± 0.4 m·s-1和在5MHz时的声学衰减为6.1 ± 0.06 dB·cm-1.
- 光学特性包括吸收μa (λ) = 0.05 ± 0.005 mm-1和散射μs' (λ) = 1 ± 0.1 mm-1在800 nm.
- 通过改变聚合物度,二氧化和油溶性染料来实现声学和光学性能的独立调整.
结论:
- 开发的材料提供了一个稳定,可复制和成本效益高的解决方案,用于多式联接声光学标准化.
- 它的生物相关性质和易于制造使其在推进生物医学成像标准方面非常有前途.
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