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西西里半百岁和超百岁的人:识别与年龄相关的T细胞免疫类型,以确定长寿特征

Mattia Emanuela Ligotti¹, Giulia Accardi¹, Anna Aiello¹

¹Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Palermo, Italy.

Clinical and experimental immunology

|July 3, 2023

概括

百岁老人表现出多样化的免疫系统衰老,受遗传学和生活经验的影响. 最老年人的某些免疫标记可能不会有害,这表明复杂的适应衰老和cytomegalovirus感染.

科学领域:

免疫学免疫学免疫学
老年学是一门学科.
细胞生物学细胞生物学

背景情况:

免疫系统随着年龄的增长而发生变化 (免疫发生) 和细胞巨乳病毒 (CMV) 感染.
了解百岁老人的免疫特征,可以了解健康的衰老.
个人的遗传和生活经历塑造了免疫系统的轨迹.

研究的目的:

研究百岁老人的免疫表型变异.
分析与年龄和CMV状况相关的T细胞子集和促炎标志物.
确定在老年人中观察到的免疫变化是否不利.

主要方法:

免疫细胞子集的流细胞计分析.
评估T细胞种群 (原始,TEMRA) 和促炎性标志物.
研究队列包括19-110岁的个人,重点关注最年长的百岁老人.

主要成果:

观察到免疫衰变标记的显著变异,与年龄和CMV血清状况有关.
最年长的百岁老人显示较低的原始T细胞和较高的T效应记忆细胞重新表达CD45RA (TEMRA) 细胞,受CMV的影响.
一些百岁以上的人表现出与年轻人相似的免疫特征,具有可管理的炎症标志物.

结论:

百岁老人的免疫衰老是高度可变的,这是由于年龄和CMV以外的因素的结合造成的.
个体免疫病史显著影响免疫系统衰老.
观察到的免疫变化,包括炎症标志物和TEMRA细胞,可能是适应性的,对百岁老人来说不会有害.

关键词:

在CMV中使用CMV.免疫衰老免疫衰老免疫类型免疫类型长寿长寿是一个问题.一半超级百岁老人半超百岁老人超级百岁老人超级百岁老人

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