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用溶剂/洗剂处理的人体血可以减少儿科,青少年和年轻成人患者过敏输血反应的复发

Wael Ibrahim¹, Stephanie Kinney²

¹Hoxworth Blood Center, University of Cincinnati Academic Health Center, Cincinnati, Ohio, USA.

|July 3, 2023

概括

用溶剂/洗剂处理的血显著减少了需要血输血或换血的儿科和年轻成人患者的过敏输血反应. 这种S/D处理等离子体为有过反应病史的患者提供了更安全的替代方案.

科学领域:

输血医学输血医学
血液学血液学血液学
免疫学免疫学免疫学

背景情况:

用溶剂/洗剂 (S/D) 处理的血Octaplas已被批准用于TTP和凝血因子缺陷.
在使用S/D治疗等离子体的儿科,青少年和年轻成年人群中,缺乏减少过敏输血反应 (ATR) 的证据.

研究的目的:

评估S/D治疗等离子体在儿童,青少年和年轻成人患者ATRs降低方面的疗效.
在需要治疗性血交换 (TPE) 或血输血 (PTs) 的患者中评估S/D处理的血的安全性和效用.

主要方法:

从2018年1月到2022年7月,单一中心对患者记录进行了回顾性审查.
对1415个单位的S/D处理血进行分析,该血被输给了9名年龄在13个月至25岁的患者.

主要成果:

由于对常规等离子体产品的轻度至重度ATR,六名患者开始接受S/D治疗等离子体.
在研究期间,在接受S/D治疗等离子体的患者中没有报告过敏或其他输血反应.
用于TPE或PT的S/D处理的血用于各种临床指示,每次体积从200至1800毫升不等.

结论:

用S/D处理的血成功地用于患有ATR的儿科,青少年和年轻成人患者,使必要的TPE或PT成为可能.
用S/D处理的血作为输血服务的有价值和安全的替代品,特别是在儿科护理中,对于容易发生ATR的患者.

关键词:

过敏的输血反应过敏的输血反应儿科儿科儿科儿科血输血儿科血输血血等离子体是什么?血输血是血输血的一种方式.聚合性血的聚合性血用溶剂/洗剂处理的聚合血.

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