横性肝脏内移植系统静脉穿插入可改善肌肉质量,但不能改善肌肉功能或肌肉脆弱度
Penelope Hey1,2, Brooke Chapman1,2,3, Darren Wong1,2
1Department of Gastroenterology, Austin Health, Heidelberg.
European journal of gastroenterology & hepatology
|July 3, 2023
概括
横性肝内移植系统突变 (TIPS) 在肝硬化患者中增加了骨肌肉质量,但没有改善肌肉功能或肌肉脆弱. 然而,胰岛素样生长因子-1和免疫功能标志物在TIPS后呈现改善.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 肌肉生理学 肌肉生理学
- 干预性放射学 干预性放射学
背景情况:
- 肝硬化患者的肉症与不良结果有关.
- 横性肝内移植系统突变 (TIPS) 改善了放射性肌肉质量,但其对肌肉功能和肌肉脆弱的影响尚不清楚.
研究的目的:
- 评估TIPS插入对肌肉功能,表现和肌肉虚弱在肝硬化患者的影响.
主要方法:
- 对接受TIPS的肝硬化患者进行前性研究.
- 通过CT扫描评估骨肌肉和脂肪组织.
- 监测手握强度,肝脏脆弱指数和身体表现.
- 测量了饮食摄入量,胰岛素抵抗,IGF-1和免疫功能 (QFM).
主要成果:
- 骨肌面积和皮下/肌肉间脂肪组织在TIPS后6个月显著增加.
- 没有观察到手握强度,虚弱或身体表现的改善.
- 胰岛素样生长因子-1 (IGF-1) 和量子菲龙监测器 (QFM) 的得分显著增加.
结论:
- 插入TIPS可以增加肌肉质量和IGF-1,肌肉生长因子.
- 功能性改善的缺乏可能是由于肌肉质量受损或高氨血.
- 改善的QFM表明感染易感性的潜在降低,需要进一步研究.
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