负性精神分裂特征患者的奖励动机适应:开发一种新的行为范式,并使用休息状态功能连接分析识别其神经相关性
Yong-Jie Yan1,2,3, Hui-Xin Hu1,4, Yi-Jing Zhang1,4
1Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Chaoyang District, Beijing, 100101, People's Republic of China.
概括
具有高负性精神分裂特征 (NS) 的个体表现出受损的奖励动机适应能力,无法适应努力-奖励失衡. 他们的大脑是他们的大脑.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 与对照组相比,具有高负性精神分裂特征 (NS) 的个体表现出较低的奖励动机.
- 根据努力-奖励比率和高NS中相关的神经机制的奖励动机的适应性变化仍然不清楚.
研究的目的:
- 为了研究奖励动机如何适应变化与高NS的个体不同的努力奖励比率变化.
- 确定与高NS中奖励动机相关的静止状态功能连接 (rsFC) 模式.
主要方法:
- 招募了35名高NS和44名低NS的个人.
- 进行了3T休息状态功能性脑部扫描和一个新的奖励动机适应行为任务.
- 行为任务包括努力>奖励,努力<奖励和努力=奖励条件,评估"想要"和"喜欢"评级; rsFC分析是基于种子和voxel的.
主要成果:
- 在努力>奖励条件下,高NS个体在"想要"和"喜欢"方面显著下降.
- 与对照组相比,奖励动机在努力 (奖励条件) 中没有像对照组那样反弹.
- 在高NS群体中观察到改变的rsFCs,涉及前额,多巴胺基 (VTA,SN),海马,丘脑和小脑区域.
结论:
- 具有高NS的个体表现出受损的奖励动机适应,其特点是在努力-奖励不平衡期间无法调整.
- 关键大脑区域的休息状态功能连接的改变是奖励处理中的这种适应性缺陷的基础.
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