变性人和性别多元青年人群的骨健康
Janet Y Lee1,2,3
1Department of Pediatrics, Division of Pediatric Endocrinology, University of California, San Francisco, San Francisco, CA, 94143, USA. Janet.Lee@ucsf.edu.
Current osteoporosis reports
|July 3, 2023
概括
变性人和性别多样性 (TGD) 的年轻人在开始性别肯定护理之前,通常骨密度较低. 医学治疗可以在关键发育阶段影响骨密度,需要进一步研究.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 骨生物学 骨生物学
- 青少年医学 青少年医学
背景情况:
- 跨性别和性别多样性 (TGD) 的青少年在骨发育的关键时期可能会启动性别肯定医学疗法.
- 治疗前的评估显示,TGD年轻人的低骨密度与年龄相比的患病率高于预期.
- 鉴于医疗干预对骨积累的潜在影响,了解这一群体的骨健康至关重要.
研究的目的:
- 审查和综合有关跨性别和性别多样性 (TGD) 青年骨健康的当前科学证据.
- 突出TGD年轻人在医疗干预之前和期间患有骨密度问题的普遍性.
- 为了确定与TGD青少年骨健康下降相关的风险因素.
主要方法:
- 对TGD年轻人骨健康研究的系统文献综述.
- 分析骨矿物质密度Z-分数与性别确认疗法 (性腺激素释放激素激素激动剂,雌激素,丸激素) 相比.
- 在TGD青少年中识别和总结低骨密度的危险因素.
主要成果:
- 在开始性别肯定医学治疗之前,TGD年轻人表现出低骨密度的比预期更高的比率.
- 骨矿物质密度Z-分数显示,随着性腺激素释放激素激动剂的减少,以及随后对雌激素或的多样化反应.
- 低骨密度的确定的危险因素包括低体重指数,减少体力活动,出生时分配的男性性别和维生素D缺乏.
结论:
- 对于TGD年轻人来说,骨健康是一个重要的关注点,许多人在治疗前表现出低骨密度.
- 性别确认疗法可以影响青春期的骨密度轨迹,需要仔细监测.
- 进一步的研究对于阐明接受医学干预的TGD年轻人的长期骨质增加和未来骨折风险至关重要.
相关概念视频
01:29Bone Disorders
3.7K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.7K
01:17Hormones and Bone Tissue
2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K
01:25Role of Vitamins in Maintaining Bone Health
3.5K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.5K
01:31Essential Minerals for Bone Health
4.2K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
4.2K
01:20Introduction to the Skeletal System
5.9K
The skeletal system is the central framework of the body, consisting of different connective tissues: bones, cartilage, tendons, and ligaments.
Components of the Skeletal System
Bone, or osseous tissue, is a hard connective tissue that forms an internal support structure for the human body. Bones shield vulnerable organs and soft tissue from external forces. For example, the vertebral bones protect and support the spinal cord.
Cartilage, a semi-rigid connective tissue found in regions such as...
Components of the Skeletal System
Bone, or osseous tissue, is a hard connective tissue that forms an internal support structure for the human body. Bones shield vulnerable organs and soft tissue from external forces. For example, the vertebral bones protect and support the spinal cord.
Cartilage, a semi-rigid connective tissue found in regions such as...
5.9K
01:09Changes in the Appendicular Skeleton with Age
2.1K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
2.1K