从系统性黑色素瘤治疗中诊断和管理皮肤学不良事件
Christopher J Fay1, Samantha Jakuboski2, Beth Mclellan3
1Department of Dermatology, Brigham and Women's Hospital, and the Center for Cutaneous Oncology, Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston, MA, USA.
American journal of clinical dermatology
|July 3, 2023
概括
皮肤不良反应在先进的黑色素瘤治疗中很常见,如向疗法和免疫疗法. 了解这些毒性对于有效的诊断,管理和改善患者结果至关重要.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 先进的黑色素瘤管理已经被蛋白质激酶抑制剂和免疫疗法彻底改变.
- 这些治疗方法虽然有效,但可能会导致严重的与药物相关的毒性,影响多个器官系统.
- 皮肤学不良事件是一个值得关注的问题,影响患者的生活质量和治疗结果.
研究的目的:
- 审查与向黑色素瘤疗法 (BRAF和MEK抑制剂) 和其他治疗相关的皮肤学不良事件.
- 专注于这些皮肤毒性的诊断和管理.
- 简要讨论可注射的塔利摩根拉赫帕雷维克和最近的免疫疗法进展.
主要方法:
- 针对性和其他黑色素瘤治疗的皮肤学不良事件的文献综述.
- 专注于诊断标准和建立的管理策略.
- 包括最近关于talimogene laherparepvec和免疫治疗突破的数据.
主要成果:
- 向疗法 (BRAF/MEK 抑制剂) 和其他黑色素瘤治疗方法经常导致各种皮肤学不良事件.
- 这些皮肤毒性会显著影响患者的生活质量.
- 皮肤学不良事件通常与治疗反应和整体存活率相关.
结论:
- 临床医生必须意识到与黑色素瘤治疗相关的皮肤毒性的各种表现.
- 迅速和准确的诊断和皮肤不良事件的管理是必不可少的.
- 有效管理这些毒性对于维持患者的生活质量和潜在地改善生存结果至关重要.
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