患者与克洛斯特里迪奥伊德困难感染及其治疗的经验:一个系统的文献审查
Edward P Armstrong1, Daniel C Malone2, Duska M Franic3
1Strategic Therapeutics and University of Arizona College of Pharmacy, Tucson, AZ, USA.
Infectious diseases and therapy
|July 3, 2023
概括
困难杆菌感染 (CDI) 严重影响患者的健康相关生活质量 (HRQoL),造成持久的身体,情绪和社会痛苦. 复发性CDI (rCDI) 加剧了这些衰弱效应,突出了未满足的医疗需求.
科学领域:
- 传染性疾病 传染性疾病
- 胃肠病学 胃肠病学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 艰难结核菌感染 (CDI) 是疾病和死亡的重要原因,对患者的福祉有深远的影响.
- CDI的人文负担,包括与健康相关的生活质量 (HRQoL),需要进行彻底的调查.
研究的目的:
- 系统地审查关于CDI患者体验的文献,重点关注HRQoL和相关结果.
- 评估患者对CDI现有和替代治疗的态度.
主要方法:
- 按照PRISMA指南进行了系统文献审查 (SLR).
- 在PubMed,Embase和Cochrane图书馆进行了搜索,寻找2010年至2021年的英语文章.
- 包括研究评估了CDI或复发性CDI (rCDI) 和患者报告的结果或HRQoL.
主要成果:
- 在最初确定的511篇文章中,有21篇文章符合纳入标准.
- CDI显著降低了整体HRQoL,其影响在感染后仍然存在.
- 对身体,情感,社会和职业福祉的影响是巨大的,特别是对于rCDI患者,他们报告孤立,抑郁和恐惧复发.
结论:
- CDI和rCDI是使人衰弱的疾病,对患者长期生活的多个方面产生负面影响.
- 需要加强预防,心理支持和针对微生物组的治疗来管理CDI.
- 开发额外的安全有效的治疗方法对于解决这一未满足的医疗需求至关重要.
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