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在最初的呈现时,未知原发性骨转移性癌症的骨转移性癌症

Masatake Matsuoka¹, Tomohiro Onodera², Isao Yokota³

¹Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, North 15 West 7, Kita-Ku, Sapporo, Hokkaido, 060-8638, Japan. masatakem@pop.med.hokudai.ac.jp.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

|July 3, 2023

概括

不知原发性骨转移性癌症 (CUP) 的预后不佳. 然而,化疗和放射治疗等治疗方法可以改善大多数亚型的生存率,除了神经内分泌.

科学领域:

在瘤学瘤学.
癌症研究癌症研究
流行病学流行病学

背景情况:

未知原发性癌症 (CUP) 是一个重大的临床挑战.
在CUP中,骨转移表明预后不佳.

研究的目的:

调查骨转移性CUP患者的临床特征和预后.
使用监测,流行病学和最终结果 (SEER) 数据库进行基于人口的分析.

主要方法:

从SEER数据库 (2010-2018) 中识别了1908名骨转移性CUP患者.
组织学分为腺癌,状细胞癌,神经内分泌癌和其他未指明的癌症 (NOS).
采用Cox的比例危险建模,考虑年龄,性别,种族,组织学和治疗.

主要成果:

腺癌组织学与更短的生存时间有关.
化学疗法 (28%) 和放射治疗 (34%) 给了一小部分患者.
平均存活时间为2个月;治疗改善了状细胞,腺癌和NOS的存活率,但不是神经内分泌的.

结论:

骨转移性CUP表现出极其糟糕的预后.
化疗和放射治疗通常提供生存益处.
进一步的随机试验是必要的,以验证这些发现.

关键词:

不知原因的原发性癌症.新生体分类的新生体分类.追溯研究是一项回顾性研究.在 SEER 计划中,治疗结果的结果.

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