相关实验视频

Updated: Jul 24, 2025

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Published on: July 19, 2024

阴仁唐通过增加NR1H4和APOA1表达来缓解高脂肪饮食诱导的NAFLD

Li Xu¹, Hongliang Cui¹

¹Medical Experiment Center, Shaanxi University of Chinese Medicine, Xianyang, 712046, China.

Journal of traditional and complementary medicine

|July 3, 2023

概括

宁唐 (YCHT) 通过减少肝脂肪和改善肝脏健康,有效治疗非酒精性脂肪性肝病 (NAFLD). 这种传统中医药调节了NR1H4和APOA1等关键点,以获得治疗效益.

科学领域:

肝病学肝病学是一种肝病学.
药理学药理学是指药理学的学科.
传统中国医药传统中国医药

背景情况:

非酒精性脂肪肝 (NAFLD) 是一个日益严重的健康问题.
传统中医药的 (Yinchenhao Tang,简称YCHT) 显示出对NAFLD治疗的前景.
YCHT对NAFLD的确切剂量效应和分子标仍然不清楚.

研究的目的:

研究不同度的YCHT对NAFLD的治疗效果.
为了确定YCHT在NAFLD调制中的潜在分子标.
评估YCHT对NAFLD肝病理和脂质代谢的影响.

主要方法:

在昆明小鼠中使用高脂肪饮食 (HFD) 诱导NAFLD.
小鼠接受了不同度的YCHT治疗.
网络药理学,qPCR,西部涂抹和免疫组织化学用于识别标并评估NR1H4和APOA1.1的表达.

主要成果:

在NAFLD小鼠中,YCHT显著降低了肝脂积累,改善了肝病理.
中高剂量的YCHT显著降低了血清脂质水平和肝酶 (ALT,AST).
通过YCHT治疗可以提高NR1H4和APOA1的表达,而这两种表达被HFD抑制.

结论:

YCHT有效地改善了HFD引起的NAFLD.
YCHT的治疗效果通过调节NR1H4和APOA1.1来调节.
YCHT证明了作为NAFLD治疗的潜力.

关键词:

在 APOA1A1 中,APOA1A1是APOA1A.脂质新陈代谢脂质新陈代谢这是NAFLD.在NR1H4中,它是NR1H4的.宁晨 (Yinchenhao) 唐 (Tang) 是一个中国的

更多相关视频

Investigating the Protective Effects of Platycodin D on Non-Alcoholic Fatty Liver Disease in a Palmitic Acid-Induced In Vitro Model

Investigating the Protective Effects of Platycodin D on Non-Alcoholic Fatty Liver Disease in a Palmitic Acid-Induced In Vitro Model

Published on: December 2, 2022

Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis

Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis

Published on: March 11, 2017

相关概念视频

Atherosclerosis III: Management

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...

Transducer Mechanism: Nuclear Receptors

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:

Cholesterol: Significance and Regulation

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...