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系统性炎症与心肌梗塞后创伤后应激障碍的相关性

Peter T Buto¹, Amit Shah^1,2,3, Brad D Pearce¹

¹Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.

Brain, behavior, & immunity - health

|July 3, 2023

概括

炎症标志物预测在年轻/中年肌动脉梗塞 (MI) 幸存者中增加创伤后应激障碍 (PTSD) 症状,特别是黑人. 这表明炎症可能与心血管疾病和PTSD发展有关.

科学领域:

心血管疾病是什么心血管疾病
心理健康心理健康
免疫学免疫学免疫学

背景情况:

在心肌梗塞 (MI) 后,诸如抑郁症,PTSD和焦虑等不良心理健康状况很常见.
连接心理健康状况和不良心血管结果的机制尚未完全理解.
据假设,炎症途径可以调解这些关联.

研究的目的:

为了检查PTSD症状和炎症生物标志物在年轻/中年后MI人口之间的双向关联.
根据性别和种族来调查这种关联中的潜在差异.

主要方法:

包括244名年龄在25-60岁的患者,患有早期发作的心脏病发作.
收集了有关抑郁症,PTSD,感知压力,焦虑和炎症生物标志物 (IL-6,hsCRP) 在基线和6个月后期的数据.
分析了心理健康症状和炎症生物标志物的双向变化.

主要成果:

基线炎症标志物 (IL-6和hsCRP) 与6个月后PTSD复发症状的增加显著相关.
每个hsCRP单位的增加与PTSD症状增加1.58个点相关 (p=0.01).
每个单位的IL-6增加与PTSD症状增加2.59点相关 (p=0.02).
这种关联主要观察到黑人个体,而不是其他种族群体.
基线心理健康得分并不总是预测炎症生物标志物的变化.

结论:

炎症标志物与年轻/中年MI患者,特别是黑人患者的PTSD症状增加有关.
研究结果表明,在心血管疾病患者中,炎症和PTSD发展之间存在潜在的机械联系.

关键词:

炎症炎症是一种炎症.纵向研究是一项纵向研究.心肌梗塞的心脏病发作创伤后应激障碍创伤后应激障碍

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