针对SAMHD1:克服多种抗癌药物在血液恶性瘤中的耐药性
Tao Wang1, Ping Liu1, Jianmin Yang1
1Department of Hematology, Institute of Hematology, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Genes & diseases
|July 3, 2023
概括
无菌的α基因和含有蛋白质1 (SAMHD1) 的histidine/aspartic acid域调节了脱氧核酸三酸盐池并影响了细胞功能. 这篇评论探讨了SAMHD1的情况.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 血液学 血液学 血液学
背景情况:
- 无菌的α基因和含有蛋白质1 (SAMHD1) 的histidine/aspartic acid域是一个dNTPase,对于维持细胞内dNTP池平衡至关重要.
- SAMHD1 影响细胞增殖,细胞循环,基因组稳定性和先天免疫力,其活性通过翻译后修饰来调节.
- SAMHD1的突变与慢性淋巴细胞白血病和地幔细胞淋巴瘤等血液性恶性瘤有关,其表达预测急性髓性白血病的预后不佳.
研究的目的:
- 审查SAMHD1.1的功能和调节.
- 为了阐明SAMHD1和血液性恶性瘤之间的关联.
- 总结SAMHD1在调解各种抗癌药物耐药性的作用,并讨论潜在的治疗策略.
主要方法:
- 文献综述侧重于SAMHD1的生物化学功能.
- 对将SAMHD1与血液性恶性瘤联系起来的研究进行分析.
- 关于SAMHD1在药物耐药性机制中的作用的证据汇编.
主要成果:
- SAMHD1的dNTPase活性是其功能的核心.
- 在血液癌症中,SAMHD1的表达和突变是显著的.
- SAMHD1对核糖类相似物,拓酶抑制剂,剂和低甲基化剂以及间接对其他疗法产生耐药性.
结论:
- SAMHD1在血液性恶性瘤的发病和耐治疗性方面发挥着至关重要的作用.
- 向SAMHD1是一个有希望的策略,以克服耐药性血液癌症的药物耐药性.
- 开发新的SAMHD1向剂可以显著改善患者的治疗结果.
相关概念视频
Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
Cancer Stem Cells and Tumor Maintenance
5.0K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
5.0K
Stem Cell Therapy for Tissue Regeneration
4.1K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.1K
Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K


