血清费里丁,D-Dimer和C-反应性蛋白质参数在COVID 19严重性中的作用
Z Abdullateef Abdullah1, L Fouad Ali1
1Department of Biology, College of Science, University of Baghdad, Baghdad, Iraq.
Archives of Razi Institute
|July 3, 2023
概括
像费里丁,D-二聚体和C反应蛋白 (CRP) 这样的生物标志物随着COVID-19的严重程度显著增加. 这些指标对于评估疾病进展和冠状病毒感染患者的结果至关重要.
科学领域:
- 病毒学 病毒学
- 临床生物化学 临床生物化学
- 流行病学 流行病学
背景情况:
- 严重急性呼吸道综合征-冠状病毒2 (SARS-CoV-2) 导致COVID-19,这是一个具有多种并发症的重大全球健康威胁.
- 了解临床表现和生化标志物之间的相关性对于管理疾病至关重要.
研究的目的:
- 研究生物化学标记物 (D-Dimer,ferritin,CRP) 与伊拉克患者COVID-19的严重程度之间的关联.
- 评估这些标记物在预测疾病进展和患者结果方面的有用性.
主要方法:
- 分析了来自伊拉克医院的170个临床样本 (100名COVID-19患者,70名对照).
- 用于检测SARS-CoV-2的RT-PCR和对D-Dimer,费里丁和C反应蛋白 (CRP) 水平的生物化学分析.
- 根据感染严重程度 (轻度,中度,严重,危急) 和年龄组对患者进行分类.
主要成果:
- 在所有重症组中观察到费里丁,D-二次体和CRP的显著升高,严重病情患者的显著增加 (p<0.001).
- 升高的费里水平在危急病患者中最为明显 (545.58 ± 57.71).
- D-二次数 (3.93 ± 0.79) 和CRP (96.27 ± 14.55) 显著增加,特别是在关键组.
结论:
- 生物化学标记物D-Dimer,ferritin和CRP与COVID-19的严重程度密切相关.
- 这些标志物是评估SARS-CoV-2感染患者疾病进展和临床结果的有价值指标.
- 50-60岁的年龄组显示出更严重疾病的趋势,而性别没有显著影响严重程度.
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