特尼福利皮龙A-J:来自Isodon ternifolius (D. Don) Kudô的新的细胞毒性α-pyrones
Abdelsamed I Elshamy1, Tarik A Mohamed2, Ningombam Swapana3,4
1Chemistry of Natural Compounds Department, National Research Centre 33 El Bohouth St., Dokki Giza 12622 Egypt elshamynrc@yahoo.com.
RSC advances
|July 3, 2023
概括
从Isodon ternifolius根源中确定了十种新的α-pyrone衍生物. 乌尔索酸显示出对白血病和乳腺癌细胞系的显著增长抑制潜力.
科学领域:
- 自然产品化学 自然产品化学
- 药用化学 医学化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 伊索登·特尼福利乌斯 (Isodon ternifolius) 是一种具有传统医疗用途的亚洲草药.
- 对I. ternifolius根的二甲-甲醇提取物进行了生物活性化合物分析.
研究的目的:
- 从I. ternifolius根源中分离和描述化合物.
- 评估这些化合物对癌症细胞系的细胞毒性潜力.
主要方法:
- 使用染色学分离化合物.
- 通过NMR光谱学和质谱学阐明结构.
- 用X射线晶体学和电子圆形二元化 (ECD) 来确定绝对配置.
- 针对CCRF-CEM白血病,MDA-MB-231和MCF7细胞系的体外细胞毒性测定.
主要成果:
- 分离了19种化合物,包括10种新型α-pyrone衍生物 (ternifolipyrons A-J).
- 化合物7,10,12,15-17显示出对CCRF-CEM白血病细胞的显著增长抑制.
- 乌尔索酸 (16) 显示出强烈的活性,其IC50值为8.37μM (白血病),18.04μM (MDA-MB-231) 和18.93μM (MCF7).
结论:
- 这项研究发现了来自I. ternifolius的新型α-pyrone衍生物.
- 这种草本中的乌尔索酸显示出有前途的抗癌活性,需要进一步研究.
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