疾病相关的代谢途径受到重金属和金属化物影响
Zinia Haidar1, Kaniz Fatema1, Sabrina Samad Shoily1
1Department of Genetic Engineering & Biotechnology, University of Dhaka, Dhaka 1000, Bangladesh.
Toxicology reports
|July 3, 2023
概括
环境中的重金属如和暴露与慢性代谢障碍有关. 这篇评论详细介绍了这些金属如何破坏细胞通路,导致糖尿病和神经退行等疾病.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 环境中的重金属和金属化物暴露的增加对人类健康构成重大风险.
- 暴露在重金属和慢性,与年龄相关的代谢障碍之间的联系是一个越来越令人担忧的领域.
- 这些毒性背后的分子机制是复杂的,并未完全理解.
研究的目的:
- 通过重金属和金属化物暴露而改变的与疾病相关的代谢和信号通路进行审查.
- 探索各种重金属和金属体的冲击机制.
- 研究受影响路径与慢性多因子疾病的关联,包括糖尿病,心血管疾病,癌症,神经退行,炎症和过敏反应.
主要方法:
- 文献综述总结了当前关于重金属诱导的代谢和信号通路改变的知识.
- 对特定金属的影响的分析: (As), (Cd), (Cr),铁 (Fe), (Hg), (Ni) 和 (V).
- 检查改变路径与各种慢性疾病之间的关系.
主要成果:
- 重金属和金属化物改变特定的代谢和信号通路.
- 在受不同金属影响的细胞通路中存在显著的重叠,但不同的通路也受到影响.
- 这些变化与主要慢性疾病的发病有关.
结论:
- 暴露于重金属和金属化物对细胞代谢和信号传递有显著影响.
- 了解这些受影响的途径对于理解慢性疾病的发展至关重要.
- 常见的受影响路径为治疗金属诱导病理的治疗干预提供了潜在的目标.
关键词:
亚是一种.是的组成部分.(Chromium) 是一种含的物质.与疾病相关的代谢途径.这是一种重金属,重金属.铁铁铁是什么意思 铁铁铁水星 水星 水星 水星 水星这是一种金属化物.尼克尔 尼克尔是什么意思瓦纳是一种.更多相关视频
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