在怀孕和早产期间的孕妇的血和唾液无病毒
Chandrashekara Kyathanahalli1,2, Madeline Snedden1, Lavisha Singh3
1Department of Obstetrics and Gynecology, NorthShore University HealthSystem, Evanston, IL, United States.
Frontiers in medicine
|July 3, 2023
概括
扭矩病毒 (TTV) 和扭矩迷你病毒 (TTMV) 在怀孕期间很常见. 血中的第三季度扭矩小病毒 (TTMV) 可能与自发早产有关,但需要更多的研究.
科学领域:
- 病毒学 病毒学
- 产科 产科 产科 产科 产科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 人类的anelloviruses,Torque teno病毒 (TTV) 和Torque teno迷你病毒 (TTMV),广泛存在,通常被认为是非致病性.
- 它们在怀孕期间的患病率和病毒载荷以及与早产的潜在关联尚未得到充分了解.
研究的目的:
- 调查怀孕期间母亲血和唾液中TTV和TTMV的流行率和病毒载量.
- 评估TTV和TTMV与自发或医疗指示的早产之间的关联.
主要方法:
- 测量母亲压力 (MOMS) 研究的二次分析 (n=744).
- 案例控制设计比较自发早产 (sPTB),医学上指示的早产 (iPTB) 和到期分娩控制.
- 实时PCR用于检测和量化TTV和TTMV在血和唾液样本的第二和第三个三个月.
主要成果:
- 在整个怀孕期间,TTV和TTMV在血和唾液中非常普遍.
- 在sPTB,iPTB和对照组中,TTV流行率和病毒载量没有显著差异.
- 第三个三个月的血扭矩小病毒 (TTMV) 与自发早产 (sPTB) 和分娩时更早的妊娠年龄有关.
结论:
- 在孕期第三季度,在母体血中存在阿内洛病毒,特别是TTMV,可能与早产有关.
- 在早产中TTMV的潜在致病作用需要进一步调查.
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