相关实验视频
Updated: Jul 24, 2025
06:48
An Orthotopic Murine Model of Human Prostate Cancer Metastasis
Published on: September 18, 2013
35.2K
内分泌细胞和状细胞癌
Sarah K Hakuno1, Stefanus G T Janson1, Marjolijn D Trietsch2,3
1Department of Gastroenterology-Hepatology, Leiden University Medical Center, Leiden, Netherlands.
Frontiers in medicine
|July 3, 2023
概括
内分泌蛋白在状细胞癌 (SCC) 细胞上表达,影响膜信号传递,但没有直接影响癌细胞的增殖或迁移. 这项研究阐明了内分泌蛋白在头,食道和癌中的作用.
科学领域:
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
- 分子信号传输的方法
背景情况:
- 内分泌蛋白对内皮细胞的作用是明确的,但其对上皮癌细胞的表达和功能,特别是状细胞癌 (SCC),仍然不清楚.
- 在SCC中研究内素对于了解癌症生物学和潜在的治疗点至关重要.
研究的目的:
- 确定内分泌蛋白在头部和部 (HNSCC),食道 (ESCC) 和阴道 (VSCC) 状细胞癌中的表达和功能作用.
- 阐明内分泌蛋白在SCC细胞内的TGF-β信号通路中的参与.
主要方法:
- 分析了瘤样本和14个患者衍生的SCC细胞系,以检测内分泌素的表达.
- 内分泌蛋白过度表达,被淘汰,或其信号被阻止,使用TRC105抗体来评估功能影响.
- 测量了BMP-9诱导的SMAD1酸化以评估TGF-β通路活性.
主要成果:
- 内分泌蛋白被瘤巢内的单个SCC细胞选择性地表达,在HNSCC,ESCC和VSCC细胞系中表达水平的患者间显著变化.
- BMP-9信号导致SMAD1酸化,独立于ALK1受体表达.
- 内分泌物过度表达增加了可溶性内分泌物水平,随后减少了BMP-9信号传递;然而,内分泌物没有直接影响SCC细胞的增殖或迁移.
结论:
- 内分泌蛋白在瘤巢中的单个SCC细胞上表达,在膜信号传递中发挥作用.
- 溶性内分泌蛋白调节BMP-9信号,但内分泌蛋白不会直接影响SCC的增殖或迁移.
相关概念视频
02:38Mitogens and the Cell Cycle
6.6K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.6K
01:19Cadherins in Tissue Organization
3.0K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
Cell Sorting During Development
Cell sorting plays an...
3.0K
01:20Classification of Epithelial Tissues: Glandular Epithelium
8.9K
The glandular epithelium is made of one or more epithelial cells modified to synthesize and secrete chemical substances. Glandular epithelia can be classified based on cell number. Unicellular glands have individual secretory cells scattered across the epithelial monolayer. In contrast, multicellular glands consist of a hollow tubular duct attached to the cluster of secretory cells located in the deep pockets.
Multicellular glands are formed during early development when epithelial budding...
Multicellular glands are formed during early development when epithelial budding...
8.9K