Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

6.6K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.6K
Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

3.0K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
3.0K
Classification of Epithelial Tissues: Glandular Epithelium01:20

Classification of Epithelial Tissues: Glandular Epithelium

8.9K
The glandular epithelium is made of one or more epithelial cells modified to synthesize and secrete chemical substances. Glandular epithelia can be classified based on cell number. Unicellular glands have individual secretory cells scattered across the epithelial monolayer. In contrast, multicellular glands consist of a hollow tubular duct attached to the cluster of secretory cells located in the deep pockets.
Multicellular glands are formed during early development when epithelial budding...
8.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Genome near-haploidization in CDC73-wildtype parathyroid tumors.

Scientific reports·2026
Same author

Second-line oxaliplatin reintroduction or paclitaxel-ramucirumab in metastatic gastroesophageal cancer: a population-based study.

Therapeutic advances in medical oncology·2026
Same author

Endoscopic Ultrasonography-Guided Gastroenterostomy Is More Cost Effective Than Surgical Gastrojejunostomy: A Health-Economic Evaluation Alongside a Randomized Trial.

United European gastroenterology journal·2026
Same author

The SALV-Dataset Registry: An Expertly Curated Digital Clinicopathological Dataset for Salivary Gland Tumor Research and AI-Assisted Diagnostic Tools.

Head and neck pathology·2026
Same author

Time to Refresh: Design and Evaluation of Refresher Training to Sustain Procedural Teaching Skills.

Perspectives on medical education·2026
Same author

Rhesus Antagonism Is Associated With Non-Anastomotic Biliary Strictures After Orthotopic Liver Transplantation From Brain-Death Donors.

Clinical transplantation·2026

相关实验视频

Updated: Jul 24, 2025

An Orthotopic Murine Model of Human Prostate Cancer Metastasis
06:48

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

35.2K

内分泌细胞和状细胞癌.

Sarah K Hakuno1, Stefanus G T Janson1, Marjolijn D Trietsch2,3

  • 1Department of Gastroenterology-Hepatology, Leiden University Medical Center, Leiden, Netherlands.

Frontiers in medicine
|July 3, 2023
PubMed
概括
此摘要是机器生成的。

内分泌蛋白在状细胞癌 (SCC) 细胞上表达,影响膜信号传递,但没有直接影响癌细胞的增殖或迁移. 这项研究阐明了内分泌蛋白在头,食道和癌中的作用.

关键词:
美国BMP-9战斗机在TGF-β的基础上.在TRC1055中,我们可以看到TRC105.它们是内鸟类.状细胞癌的癌症.

更多相关视频

Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma
12:03

Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma

Published on: July 25, 2011

19.4K
Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
10:43

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

3.4K

相关实验视频

Last Updated: Jul 24, 2025

An Orthotopic Murine Model of Human Prostate Cancer Metastasis
06:48

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

35.2K
Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma
12:03

Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma

Published on: July 25, 2011

19.4K
Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
10:43

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

3.4K

科学领域:

  • 在瘤学瘤学.
  • 细胞生物学 细胞生物学
  • 分子信号传输的方法

背景情况:

  • 内分泌蛋白对内皮细胞的作用是明确的,但其对上皮癌细胞的表达和功能,特别是状细胞癌 (SCC),仍然不清楚.
  • 在SCC中研究内素对于了解癌症生物学和潜在的治疗点至关重要.

研究的目的:

  • 确定内分泌蛋白在头部和部 (HNSCC),食道 (ESCC) 和阴道 (VSCC) 状细胞癌中的表达和功能作用.
  • 阐明内分泌蛋白在SCC细胞内的TGF-β信号通路中的参与.

主要方法:

  • 分析了瘤样本和14个患者衍生的SCC细胞系,以检测内分泌素的表达.
  • 内分泌蛋白过度表达,被淘汰,或其信号被阻止,使用TRC105抗体来评估功能影响.
  • 测量了BMP-9诱导的SMAD1酸化以评估TGF-β通路活性.

主要成果:

  • 内分泌蛋白被瘤巢内的单个SCC细胞选择性地表达,在HNSCC,ESCC和VSCC细胞系中表达水平的患者间显著变化.
  • BMP-9信号导致SMAD1酸化,独立于ALK1受体表达.
  • 内分泌物过度表达增加了可溶性内分泌物水平,随后减少了BMP-9信号传递;然而,内分泌物没有直接影响SCC细胞的增殖或迁移.

结论:

  • 内分泌蛋白在瘤巢中的单个SCC细胞上表达,在膜信号传递中发挥作用.
  • 溶性内分泌蛋白调节BMP-9信号,但内分泌蛋白不会直接影响SCC的增殖或迁移.