Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

15.3K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Targeting TIME With Phytochemicals: A Promising Approach Against Lung Cancer.

Phytotherapy research : PTR·2026
Same author

Synergizing Schottky/S-Scheme Dual-Junction With Cu/Pb Dual-Site in a 0D/3D Cu@CsPbBr<sub>3</sub>/g-C<sub>3</sub>N<sub>4</sub> Heterojunction for Efficient CO<sub>2</sub>-to-C<sub>2</sub>H<sub>4</sub> Photoreduction.

Angewandte Chemie (International ed. in English)·2026
Same author

Radiomics-assisted unsupervised clustering and predictive modeling to identify optimal candidates for virtual navigation bronchoscopy localization and CT-guided localization in thoracoscopic lung resection.

Medicine·2026
Same author

Source, transport and impact of biomass burning emissions in spring 2024 in Yunnan, China.

Journal of environmental sciences (China)·2026
Same author

Safety and Efficacy of Obinutuzumab β (MIL62), a Novel Glycoengineered Type II Anti-CD20 Monoclonal Antibody, in Patients with Neuromyelitis Optica Spectrum Disorder: A Multicenter, Single-Arm, Phase Ib Clinical Trial.

Neurology and therapy·2026
Same author

Hepato-ocular crosstalk: Bile acids bridging pathogenesis and therapy.

iScience·2026

相关实验视频

Updated: Jul 24, 2025

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage
07:13

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage

Published on: February 10, 2023

2.3K

多态和NIHL:一个系统的审查和元分析.

Lu Wang1, HanYu Wang1, Feng Xiang1

  • 1Clinical Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

Frontiers in cellular neuroscience
|July 3, 2023
PubMed
概括

这一元分析确定了与噪音引起的听力损失 (NIHL) 易感性相关的特定基因多态性. 这些发现对于开发风险预测系统来预防高风险人群中的NIHL至关重要.

关键词:
猫猫猫猫猫猫猫猫猫猫猫猫猫猫猫EYA4YA4 在线观看GRHL2 GRHL2 的时间在HSP70中,HSP70是这是一个元分析.噪音引起的听力损失多形态主义的多态主义.

更多相关视频

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
09:44

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Published on: January 25, 2016

19.3K
Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R
06:01

Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R

Published on: December 9, 2022

2.6K

相关实验视频

Last Updated: Jul 24, 2025

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage
07:13

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage

Published on: February 10, 2023

2.3K
Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
09:44

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Published on: January 25, 2016

19.3K
Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R
06:01

Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R

Published on: December 9, 2022

2.6K

科学领域:

  • 遗传学 遗传学 是一个
  • 公共卫生 公共卫生
  • 听力学 听力学是指听力学.

背景情况:

  • 噪音引起的听力损失 (NIHL) 是一个重要的全球健康问题,受噪音暴露和遗传因素的影响.
  • 识别与个体易感性相关的遗传多态性是理解和预防NIHL的关键.
  • 之前的研究已经探索了各种遗传因素,需要进行全面的分析.

研究的目的:

  • 对经常研究的多态度进行元分析,以确定与NIHL易感性相关的基因.
  • 评估这些多态性在NIHL风险预防策略中的潜在价值.
  • 为NIHL开发有效的风险预测系统提供基础.

主要方法:

  • 在主要数据库 (PubMed,CNKI,Embase,Web of Science,Cochrane) 进行了系统的文献搜索.
  • 选了与NIHL易感性相关的多态基因研究;至少三项研究中的多态基因被纳入了元分析.
  • 使用固定或随机效应模型计算赔率比率和置信区间,评估异质性和出版偏差.

主要成果:

  • 在最初选择的64个基因中,从10个基因中分析了25个多态基因.
  • 五种多态性显示出与NIHL风险的显著关联:rs611419 (GRHL2),rs3735715 (GRHL2),rs208679 (CAT) 和rs3813346 (EYA4).
  • rs2227956 (HSP70) 与白人NIHL敏感性有显著的关联,而其他人没有显著的关联.

结论:

  • 特定的基因多态性 (GRHL2,CAT,EYA4,HSP70) 与NIHL易感性显著相关.
  • 这些已识别的多态性对NIHL风险预测和预防具有潜在价值,特别是在高风险群体中.
  • 这项研究是建立NIHL基于人口的风险预测系统的关键一步.