血管激素受体抑制剂在皮肤病理中的潜在使用
Keshvad Hedayatyanfard1,2, Azadeh Khalili1, Hosein Karim2,3
1Department of Physiology, Pharmacology and Medical Physic, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
Iranian journal of basic medical sciences
|July 3, 2023
概括
ангиотензин受体阻断剂 (ARBs) 和ACE抑制剂可以减少皮肤炎症和纤维化. 这篇评论探讨了它们在治疗诸如痕,自身免疫性疾病和癌症等皮肤疾病方面的潜力.
科学领域:
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
背景情况:
- 雷宁-血管酶系统 (RAS) 的组成部分存在于皮肤细胞中.
- 通过AT1R传递 ангиотензинII信号促进炎症和纤维化,而AT2R具有抑制作用.
- 像ARB和ACE抑制剂这样的RAS调节剂会影响皮肤的过程.
研究的目的:
- 审查ARBs在皮肤伤口愈合,缩性痕和状体中的作用.
- 探索ARB在自身免疫和自身炎症性皮肤疾病中的治疗潜力.
- 根据它们的抗纤维和抗炎性质,讨论ARB在皮肤癌中的应用.
主要方法:
- 对皮肤中RAS成分研究的文献综述.
- 对ARB和ACE抑制剂对细胞因子和纤维化因子 (TGF-β,CTGF,IL-6) 的影响的研究分析.
- 在伤口愈合,痕和炎症性皮肤疾病中检查ARB的证据.
主要成果:
- ARBs和ACE抑制剂降低了促炎性细胞因子和纤维化因子.
- 有证据表明,ARBs影响伤口愈合和痕形成.
- ARBs显示出与皮肤疾病和癌症相关的潜在抗炎和抗纤维作用.
结论:
- ARBs在治疗皮肤纤维化,炎症和相关疾病方面表现出显著的潜力.
- 对ARB的进一步研究可能会导致针对各种皮肤疾病的新型治疗策略.
- 准RAS为治疗皮肤痕,自身免疫性疾病和癌症提供了一个有希望的途径.
相关概念视频
01:30Antihypertensive Drugs: Angiotensin II Receptor Blockers
786
In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
786
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
467
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
467
01:25Antihypertensive Drugs: Direct Renin Inhibitors
699
The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
699
01:30Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
698
Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
698
01:18Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
202
Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
202
01:27Transducer Mechanism: Enzyme-Linked Receptors
2.5K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Major types that are helpful drug targets include:
2.5K