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表观遗传遗传和跨代环境正义

Alexandra A Korolenko¹, Samantha E Noll², Michael K Skinner¹

¹Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA, USA.

The Yale journal of biology and medicine

|July 3, 2023

概括

环境中有毒物质对后代的伤害比直接暴露的更大,通过表观遗传影响健康. 这突显了关于祖先暴露和公平保护的环境正义问题的关键问题.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
遗传学是一个遗传学.

背景情况:

每天向环境释放的化学物质和有毒物质对人类健康构成风险.
农业化合物虽然对作物生产有好处,但可能导致不良健康结果,包括生殖问题.
一些在欧盟被禁止的化学品仍在美国使用,这引发了监管和健康方面的担忧.

研究的目的:

调查有毒物质对直接暴露的人群和跨世代人群的影响差异.
检查表观遗传在代际毒性影响中介作用的作用.
为了强调环境正义的重要性,在祖先的毒性暴露的背景下.

主要方法:

审查有关有毒物质暴露和健康影响的现有研究.
对专注于表观遗传遗传机制的研究进行分析.
检查环境正义概念与代际健康差异的关系.

主要成果:

毒性物质通常对跨代 (祖先) 的人口表现出更深远的影响,而不是对直接暴露的代人.
表观遗传在毒剂引起的健康影响在几代人之间传播方面发挥着至关重要的作用.
对直接暴露的人群的研究优先考虑可能会忽视后代的重大长期健康负担.

结论:

跨代暴露于有毒物质是一个重要的环境正义问题,因为未来几代人可能会遭受健康后果,而不会从生产过程中受益.
当前的研究范式可能无法充分解决环境毒素的长期,代际影响.
迫切需要考虑环境正义原则,以保护未来几代人免受祖先暴露于有害化学物质造成的不成比例的伤害.

关键词:

生物医学伦理生物医学伦理这就是DDT DDT.环境正义环境正义表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.几代人的毒理学.草甘是一种天然的草甘.继承权继承权继承权有毒物质有毒物质跨世代的跨代人温克洛佐林是一种温克洛佐林.

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