在接受人环素化疗的儿科癌症患者中进行远程缺血调节:一个虚假控制的单盲随机试验
Yiu-Fai Cheung1,2, Vivian Wing-Yi Li1, Edwina Kam-Fung So1
1Department of Pediatrics and Adolescent Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong, China.
JACC. CardioOncology
|July 3, 2023
概括
远程缺血调节 (RIC) 在接受癌症治疗的儿童中没有保护他们免受环素诱导的心脏损伤. 这项研究发现,RIC和虚假组之间的心脏生物标志物或功能没有显著差异.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 儿科 儿科 儿科
背景情况:
- 人环素化疗与儿童癌症幸存者的心脏毒性有关.
- 远程缺血调节 (RIC) 已经成为一种潜在的心脏保护策略.
研究的目的:
- 评估RIC在缓解心肌损伤的疗效,在接受环素化疗的儿科癌症患者.
- 为了测试RIC可以减少心脏损伤在环素治疗期间的假设.
主要方法:
- 进行了第二阶段,单盲,随机对照试验.
- 68名儿科患者被随机分配到接受RIC或在治疗前和治疗期间接受假干预.
- 主要结局是血高灵敏性心脏托邦素T (hs-cTnT);次要结局包括心声学测量和心血管事件.
主要成果:
- 随着时间的推移,RIC和假组都显示hs-cTnT水平逐渐增加.
- 在RIC和假组之间没有观察到hs-cTnT水平或左心室功能的显著差异.
- 没有患者经历心力衰竭或心律失常.
结论:
- 远程缺血调节 (RIC) 在接受基于人环素的化疗的儿科癌症患者中没有显示出心脏保护作用.
- 这项研究不支持使用RIC作为一种策略,以防止在这个人群中预防anthracycline心脏毒性.
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