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Updated: Jul 24, 2025

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RBL2 调节心脏对环素化疗的敏感性

Peng Xia1, Jingrui Chen1, Yadav Sapkota2

  • 1Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington, USA.

JACC. CardioOncology
|July 3, 2023
PubMed
概括

视网母细胞瘤样2 (RBL2) 作为心脏中的CDK2抑制剂,防止多克索鲁比 (DOX) 心脏毒性. 失去RBL2会增加对DOX的敏感性,这表明RBL2是预测化疗引起心力衰竭风险的生物标志物.

关键词:
癌症治疗疗法 癌症治疗心肌病性心脏病 - 心肌病性心脏病心脏有毒性心脏有毒性细胞循环中的细胞循环.细胞死亡是细胞死亡.德克索鲁比辛 (doxorubicin) 是一种药物.遗传学 遗传学 遗传学 是一个心脏衰竭是因为心脏衰竭.这些机制的机制.瘤是一个瘤.

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