心脏衰竭中的心脂肪与保存的喷射部分:坏演员还是只是躺在那里?
Mary-Tiffany Oduah1, Varun Sundaram2, Yogesh Nv Reddy1
1Department of Cardiovascular Disease, Mayo Clinic Rochester, MN, US.
Cardiac failure review
|July 3, 2023
概括
保存喷射分数 (HFpEF) 的心力衰竭与肥胖有关. 本综述检查了心表脂肪是否直接导致HFpEF,或者只是与全身炎症和肥胖有关.
科学领域:
- 心脏病学 心脏病学
- 代谢综合征是代谢综合征的一种.
- 心脏病理生理学 心脏病理生理学
背景情况:
- 保持喷射分数 (HFpEF) 的心力衰竭越来越多地与肥胖和脂肪分布的改变有关.
- 副心脏脂肪可以通过机械效应和炎症媒介分泌物影响HFpEF.
研究的目的:
- 审查证据,以确定上心脂肪是否是HFpEF的直接原因或系统性脂肪的相关物.
- 讨论针对HFpEF治疗心上脂肪的治疗方法.
主要方法:
- 对调查心表脂肪在HFpEF病变发生中的作用的研究进行文献综述.
- 对直接因果关系与关联的证据分析.
主要成果:
- 胸前脂肪在HFpEF中的作用是复杂的,因为有系统性肥胖等混因素.
- 有证据表明,表心脂肪的潜在直接机械和炎症贡献.
结论:
- 需要进一步的研究来阐明心上脂肪在HFpEF中的独立作用.
- 准心上脂肪可能为HFpEF提供治疗策略.
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