定量蛋白质组学在患有非小细胞肺癌的患者中识别瘤母体体特征
Helen F Titmarsh1,2, Alex von Kriegsheim3, Jimi C Wills3
1The EPSRC and MRC Centre for Doctoral Training in Optical Medical Imaging, Queen's Medical Research Institute, University of Edinburgh, Edinburgh Bioquarter, Edinburgh, United Kingdom.
Frontiers in oncology
|July 3, 2023
概括
研究人员确定了非小细胞肺癌 (NSCLC) 瘤细胞外基质 (ECM) 的显著变化. 新的标记物,过氧化 (PXDN) 和ADAMTS16,被发现可以区分癌细胞组织,并与患者的存活率相关.
科学领域:
- 在瘤学瘤学.
- 蛋白质组学是指蛋白质组学.
- 生物化学 生物化学
背景情况:
- 细胞外基质 (ECM) 在癌症的发展,进展和治疗耐药性方面发挥着关键作用.
- 了解正常和癌症组织之间的ECM组成差异可以确定新的诊断和治疗点.
研究的目的:
- 在非小细胞肺癌 (NSCLC) 中特征瘤特异性ECM蛋白质体签名.
- 确定新型细胞外矩阵生物标记物用于NSCLC诊断和预后.
主要方法:
- 在NSCLC瘤和相邻的非恶性肺组织上使用质谱学的定量蛋白质组分析.
- 通过基因表达分析和与患者生存数据的相关性验证已识别的生物标志物.
主要成果:
- 在NSCLC和正常肺组织之间鉴定了161种不同调节的母体体蛋白.
- 发现了丰富的原氧化网络在肺瘤微环境中.
- 验证过氧化素 (PXDN) 和ADAMTS16作为NSCLC的潜在生物标志物,其高表达与患者存活率较差有关.
结论:
- 肺部细胞外基质的广泛重塑发生在NSCLC中.
- 在NSCLC中,瘤特异性母体体签名为新的诊断和预后策略提供了潜力.
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