在产前接触酒精后,微生物群和营养是风险和弹性因素
Deepa Upreti1, Siara K Rouzer1, Abigail Bowring1
1Department of Neuroscience and Experimental Therapeutics, Texas A&M University School of Medicine, Bryan, TX, United States.
Frontiers in neuroscience
|July 3, 2023
概括
产前酒精暴露 (PAE) 可能会破坏肠道微生物群,导致发育问题和胎儿酒精谱系障碍. 需要进一步的研究来理解PAE.
科学领域:
- 神经发育障碍 神经发育障碍
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 成年人暴露于酒精会导致炎症,营养不良和肠道微生物群的改变,影响营养吸收.
- 已知产前酒精暴露 (PAE) 会导致持续的炎症和营养不足.
- PAE对肠道微生物群的影响是一个新兴的研究领域.
研究的目的:
- 审查有关肠道微生物群在健康发育中的作用的现有数据.
- 探索改变肠道微生物群对PAE的影响.
- 假设肠道微生物群失调是胎儿酒精谱系障碍 (FASD) 的病因因素.
主要方法:
- 出版数据的文献审查.
- 综合成人酒精暴露研究的证据.
- 整合来自神经发育障碍研究的发现,包括自闭症谱系和注意力缺陷/多动性障碍.
主要成果:
- 肠道微生物群失调与其他神经发育障碍有关.
- 有证据表明肠道微生物群在健康发育中的作用.
- 改变的肠道微生物群是PAE终身后果的潜在贡献者.
结论:
- 肠道微生物群失调是可能导致PAE神经发育后果的病因因素.
- 改变的肠道微生物群可能在胎儿酒精谱系疾病的发病过程中发挥重要作用.
- 对PAE肠-大脑轴的进一步研究是有必要的,以了解终身健康影响.
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