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门德尔的随机分析确定了瘤亡因子与严重的COVID-19相关

Hongfei Song¹, Na Lei¹, Ling Zeng¹

¹Traditional Chinese Medicine and Inflammation Regulation Research Group, School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Frontiers in pharmacology

|July 3, 2023

概括

遗传分析表明,瘤坏死因子超级家族成员6 (FAS) 增加了COVID-19严重性风险,而TNF超级家族成员5 (CD40) 可能会提供对2019年严重冠状病毒疾病的保护.

科学领域:

免疫学免疫学免疫学
遗传学是一个遗传学.
流行病学流行病学

背景情况:

观察性研究表明,抗瘤亡因子 (TNF) 疗法可能有利于COVID-19患者.
观察性研究的方法限制阻碍了关于TNF和COVID-19的因果推断.
这项研究采用门德尔的随机化来探索TNF和COVID-19严重程度之间的因果关系.

研究的目的:

调查9个瘤亡因子 (TNF) 与2019年新冠肺炎疾病 (COVID-19) 的严重程度之间的潜在因果关系.
利用遗传数据进行强大的因果推理,克服传统观测研究的局限性.

主要方法:

使用公开可用的全基因组关联研究总结统计数据进行了两样本的门德尔随机化分析.
分析了九种TNF和严重的COVID-19的遗传关联数据.
逆方差加权 (IVW),MR-Egger和加权中位数方法用于因果估计,并进行了灵敏度分析.

主要成果:

基因预测TNF受体超级家族成员6 (FAS) 与COVID-19严重程度呈正相关性 (OR = 1.10,p = 0.026).
发现TNF受体超级家族成员5 (CD40) 对严重的COVID-19具有保护作用 (OR = 0.92,p = 0.002).

结论:

遗传证据支持FAS表达增加与患重症COVID-19风险更高之间存在关联.
CD40证明了对严重的COVID-19的潜在保护作用,需要进一步调查.

关键词:

在 COVID-19 疫情中,门德尔的随机化分析分析.因果关系,因果关系的联系.全基因组关联研究研究.瘤死亡因子是瘤死亡因子.

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