化物毒性的分子基础:超越人类疾病的好处和影响
Priyankar Pal1, Niraj Kumar Jha2,3,4, Debankur Pal1
1Department of Life Sciences, Presidency University, Kolkata, West Bengal 700073, India.
Genes & diseases
|July 3, 2023
概括
过度的化物暴露会导致氧化应激和细胞死亡,影响多个器官. 本综述详细介绍了化物毒性如何影响各种信号通路,导致器官特异性损伤和全身健康问题.
科学领域:
- 环境毒理学环境毒理学
- 细胞生物学 细胞生物学
- 生物化学 生物化学
背景情况:
- 化物的双重作用:有益于骨组织,有害于其他地方.
- 几十年来,全球都对化物对健康的不利影响感到担忧.
- 氧化应激是引发化物毒性的主要机制.
研究的目的:
- 审查过度化物暴露所针对的各种信号通路.
- 为了阐明化物的特定器官毒理机制.
- 巩固对化物对细胞和系统健康的影响的理解.
主要方法:
- 对化物毒性机制研究的文献综述.
- 参与化物诱导的细胞损伤的信号通路的分析.
- 与化物暴露相关的器官特异性异常的汇编.
主要成果:
- 化物通过自 (贝克林1,mTOR途径) 诱导细胞死亡.
- 器官特异性影响包括肝脏 (线粒体功能障碍,DNA损伤),脏 (细胞循环停止),心脏 (免疫反应) 和神经 (认知障碍) 异常.
- 生殖毒性 (类固醇生成,配体生成,出生缺陷) 和免疫系统失调是显著的结果.
结论:
- 过度的化物暴露会触发各种信号级联,导致多器官功能障碍.
- 了解这些途径对于解决化物的毒理影响至关重要.
- 对特定信号通路的进一步研究可以为预防和治疗策略提供信息.
相关概念视频
Minerals
361
Minerals are essential nutrients that the human body needs in small amounts to work properly. They play a vital role in many bodily functions, such as building strong bones and transmitting nerve impulses. Some minerals are needed for hormone production or to maintain a normal heartbeat. Major minerals include calcium, phosphorus, potassium, sulfur, sodium, chlorine, and magnesium, while trace minerals include iron, manganese, copper, iodine, zinc, cobalt, fluoride, and selenium.
Major...
Major...
361
Toxic Reactions: Overview
1.0K
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
1.0K
Essential Minerals for Bone Health
4.2K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
4.2K
Disorders of the Nervous Tissue
1.4K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
1.4K
Introduction to Electrolytes
10.4K
In humans, electrolytes play a vital role in various physiological processes. Balancing electrolyte levels is essential for normal body functions; their imbalance can be life-threatening. The major electrolytes include sodium, potassium, chloride, calcium, phosphate, and bicarbonate. They are primarily involved in physiological processes, such as nerve signal transmission, membrane trafficking, muscle contraction, buffering body fluids, and balancing water levels in the body.
Role of Sodium
One...
Role of Sodium
One...
10.4K
Electron Affinity
35.6K
The electron affinity (EA) is the energy change for adding an electron to a gaseous atom to form an anion (negative ion).
35.6K


