空气污染,细胞内到细胞外的水分发以及阻塞性睡眠呼吸暂停症状之间的关联
Cheng-Yu Tsai1,2, Huei-Tyng Huang3, Ming Liu4
1Department of Civil and Environmental Engineering, Imperial College London, London, United Kingdom.
Frontiers in public health
|July 3, 2023
概括
短期暴露于PM2.5和PM10空气污染可能会通过改变身体水分的分布来增加阻塞性睡眠呼吸暂停 (OSA) 的严重程度. 减少颗粒物污染物的暴露可能会改善OSA症状并降低风险.
科学领域:
- 环境健康 环境健康
- 睡眠医学 睡眠医学
- 心血管呼吸系统生理学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一种可能被环境因素加剧的疾病.
- 对空气污染的暴露越来越被认为是各种健康问题的危险因素,包括呼吸道和心血管疾病.
研究的目的:
- 调查体水分布在空气污染和OSA严重程度之间的关系中的调解作用.
- 确定特定空气污染物与OSA表现之间的关联.
主要方法:
- 来自台湾睡眠中心的多睡眠和身体成分数据的回顾性分析.
- 使用住宅地址和政府监测数据估计空气污染暴露 (PM2.5,PM10).
- 回归建模用于评估空气污染暴露 (1-12个月),OSA指数和体液参数之间的关联.
主要成果:
- 对PM2.5和PM10的短期暴露 (1个月) 与OSA严重程度有显著的相关性.
- 身体水分分布参数与短期 (1个月) PM2.5/PM10和中期 (3个月) PM10暴露有显著的关联.
- 身体水分发是潜在的媒介,可以加剧OSA的表现.
结论:
- 短期暴露于PM2.5和PM10可能是OSA的风险因素,可能是通过改变身体水分的分布.
- 减轻对颗粒物空气污染物的暴露可能会改善OSA的表现,并降低OSA的整体风险.
- 这项研究提供了有关空气污染,体液平衡和OSA严重性的机制的见解.
更多相关视频
相关概念视频
Sleep Apnea
195
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
195
Other Pulmonary Disorders
875
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
875
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.9K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.9K
Insufficient Sleep and Sleep Deprivation
176
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
176
Factors Affecting Pulmonary Ventilation
1.5K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
1.5K
Breathing
59.7K
The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
59.7K


