在儿科重症监护室重症肺炎儿童的元基因基因基因病原体监测
Meijin Li1, Jing Wang2, Zhongwei Yao1
1Department of Pediatric Intensive Care Unit, Guangdong Women and Children Hospital, Guangzhou, China.
Frontiers in public health
|July 3, 2023
概括
大基因组下一代测序 (mNGS) 在患有严重肺炎的儿童中确定了80种病原体. 呼吸道同胞病毒 (RSV) 和鼻病毒是常见的,并观察到高的同时感染率.
科学领域:
- 儿童传染病 儿童传染病
- 微生物基因组学 微生物基因组学
- 诊断微生物学 诊断微生物学
背景情况:
- 肺炎是儿童疾病和死亡的主要原因.
- 大基因组下一代测序 (mNGS) 提供了一种全面的方法来识别严重肺部感染的病原体.
研究的目的:
- 在儿科患者中研究严重肺炎的微生物环境.
- 为了比较mNGS与传统诊断方法的疗效.
主要方法:
- 从262名疑似肺炎的儿童收集了支气管洗液 (BALF) 样本.
- 样品使用mNGS和常规微生物学测试进行分析.
主要成果:
- 总共有80种病原体被确定.
- 呼吸道同胞性病毒 (RSV),金黄色葡萄球菌和犀牛病毒是最常见的.
- 共感染很普遍 (58.96%),其中细菌-病毒共感染是最常见的.
- 观察到了特定年龄的病原体流行,包括在6个月以下的婴儿中发现的Pneumocystis jirovecii.
结论:
- mNGS对于了解儿科肺炎的流行病学至关重要.
- 像mNGS这样的先进诊断提高了病原体检测,并为临床管理提供了信息.
相关概念视频
01:30Pneumonia III: Complications and Assessment
275
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
275
01:26Principles of Disease Surveillance
127
Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
127
01:30Pneumonia I: Introduction
281
Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
281
01:29Pneumonia II: Pathophysiology
359
The pathophysiology of pneumonia involves the following steps:
359
01:30Pneumonia V: Nursing management and Prevention
2.2K
Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
2.2K
01:28Pneumonia IV: Management
367
The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
367