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在黑色素瘤幸存者的同步和超时多重原发性癌症:性别观点

Stefano Guzzinati¹, Alessandra Buja², Giulia Grotto²

¹Veneto Tumor Registry, Azienda Zero, Padua, Italy.

Frontiers in public health

|July 3, 2023

概括

皮肤恶性黑色素瘤 (CMM) 幸存者面临后续癌症的风险增加,在甲时性非皮肤癌的发展中存在显著的性别差异. 这凸显了针对黑色素瘤患者量身定制的预防策略的必要性.

科学领域:

在瘤学瘤学.
流行病学流行病学
癌症研究癌症研究

背景情况:

皮肤恶性黑色素瘤 (CMM) 的长期幸存者有更高的后续恶性瘤的风险.
这种风险受到宿主相关因素和环境暴露的影响.
了解这些风险对于有效的二次癌症预防至关重要.

研究的目的:

调查CMM幸存者的同步和超时次性恶性瘤的风险.
通过性别和瘤部位来分析这些风险.
为CMM幸存者提供性别定制的癌症预防策略.

主要方法:

在意大利威尼托地区对9,726名CMM幸存者的回顾性基于人口的队列研究 (1999-2018).
计算同步癌症和超时癌症的标准化发病率 (SIR),不包括随后的皮肤癌.
按性别和瘤部位对分析进行分层,根据年龄和日历年份进行标准化.

主要成果:

两种性别都显示了同步癌症的SIR增加 (男性:1.90,女性:1.73).
观察到同步/尿路癌症 (男性:6.99,女性:12.11) 和女性乳腺癌 (1.69) 的风险增加.
男人患甲时性甲状腺癌和前列腺癌的风险更高,而女性患脏/尿道癌,非霍奇金淋巴瘤和乳腺癌的风险增加.

结论:

与普通人群相比,CMM幸存者患甲基慢性非皮肤癌的风险更高.
这种风险在性别之间有很大差异.
建议在CMM幸存者中进行性别特定的干预,以预防二次癌症.

关键词:

这是皮肤黑色素瘤.甲基慢性癌症是一种癌症.多种癌症多种癌症第二种原发性癌症是第二种癌症.随后的原发性癌症.同步癌症是同步的癌症.

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