在早期和晚期发病的阿尔茨海默病中,thalamic核的变化
Gonzalo Forno1,2,3, Manojkumar Saranathan4, Jose Contador1
1Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Current research in neurobiology
|July 3, 2023
概括
这就是阿尔茨海默病的原因.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 老年学是一门学科.
背景情况:
- 阿尔茨海默病 (AD) 是导致痴呆的主要原因.
- 丘陵体,特别是边缘丘陵体,因其在阿尔茨海默病症状学中的作用越来越受认可.
- 乳头核细分对于理解AD的神经病理学至关重要.
研究的目的:
- 在早期发病的AD (EOAD) 和晚期发病的AD (LOAD) 中调查乳头核缩.
- 为了比较EOAD,LOAD和健康对照 (HC) 之间的乳头缩模式.
- 为了将thalamic核体积与区域大脑缩,tau水平和认知功能相关联.
主要方法:
- 利用了Thalamus Optimized Multi Atlas Segmentation (THOMAS) 的一个深度学习变体,进行了详细的thalamic核分片.
- 分析了88名生物标志物确认的AD患者 (49名EOAD,39名LOAD) 和58名HC (41名年轻HC,17名老HC) 的T1加权MRI扫描.
- 使用MANCOVA进行群组比较和Pearson的相关性与其他生物标志物和认知分数的关联.
主要成果:
- 与HC组相比,EOAD和LOAD都表现出广泛的乳头核缩.
- EOAD显示中心中间和腹侧后核与年轻HC的额外缩.
- 胸膜缩与特定的区域大脑变化和认知缺陷相关,在EOAD和LOAD之间存在差异.
结论:
- 乳头核缩是EOAD和LOAD的重要特征.
- 乳头核参与的模式及其临床关联根据阿尔茨海默病发病的年龄不同.
- 这些发现突出了马体作为AD病理生理学的关键结构,在早期与晚期疾病发病中发挥着不同的作用.
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